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J Nucl Med. 2012; 53 (Supplement 1):62
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Oncology: Basic, Translational & Therapy

Nuclear Oncology Council YIA Symposium

Basal cell carcinoma treatment using Phosphorus-32 skin patches: A three year follow up study

Priyanka Gupta1, Somesh Gupta2, Arun Malhotra1 and Guru Bandohpadhyaya1

1 Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India 2 Dermatology, All India Institute of Medical Sciences, New Delhi, India

Abstract No. 62

Objectives: The aim of the study was to determine the efficacy of Phosphorus-32 skin patches for treatment of Basal cell carcinoma and to determine the long term effects.

Methods: Ten patients were included in the study (5 male and 5 female) aged between 32-74 years. All patients had histopathologically proven unifocal basal cell carcinoma on face. Five patients had lesion close to eyes, 4 on nose and 1 on forehead. None had invasion of underlying structures. Sealed patches incorporating P-32 (as phosphoric acid) containing 1 mCi /sq.cm were custom made according to size and shape of the lesions and applied locally on the tumour site for 3hrs.The patches were reapplied on 4th and 7th day after the first application, for 3 hrs each so as to deliver approximately 100 Gy of radiation dose superficially. Biopsies were taken from centre and margins of the lesions 3 months, 6 months, 1yr, 2 yr and 3 yrs after patch application.

Results: Histopathological examination of biopsies at 3 months from both centre and margins of the lesions were negative for any residual malignant disease in all the patients. However, a biopsy performed at 6 months revealed BCC in 2 out of 10 patients. One patient had residual BCC while other had recurrence. Biopsies of other 8 patients remained negative for BCC upto a period of 3 years. Routine haematological and biochemical examinations at the follow ups did not reveal any toxicity. There was minimal scarring of the tumour site initially and it gradually healed.

Conclusions: Basal cell carcinoma treatment using P-32 skin patches resulted in complete resolution of BCC in 8 out of 10 patients. The lesions were completely cured with no evidence of malignancy upto 3 years post treatment biopsy in 8 patients. It can be concluded that radioactive skin bandages incorporating P-32 can be effectively used for treatment of superficial skin cancers like basal cell carcinoma





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Right arrow Articles by Bandohpadhyaya, G.
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Right arrow Articles by Bandohpadhyaya, G.