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J Nucl Med. 2012; 53 (Supplement 1):505
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Oncology: Clinical Diagnosis

Hodgkin Disease and Myeloma

Analysis of the Deauville criteria for the assessment of interim PET in advanced stage Hodgkin lymphoma patients enrolled in the IVS study part I: Diagnostic accuracy and prognostic value

Lale Kostakoglu6, Alberto Biggi1, Sally Barrington3, Martin Hutchings2, Michel Meignan4, Michele Gregianin5, Stephane Chauvie1 and Andrea Gallamini1

1 S. Croce and Carle Hospital, Cuneo, Italy 2 Rigshospitalet Copenhagen, Copenhagen, Denmark 3 St.Thomas Hospital, London, United Kingdom 4 CHU H. Mondor, Paris, France 5 Oncology Institute of Veneto, Padova, Italy 6 Mount Sinai Medical Center, New York, NY

Abstract No. 505

Objectives: The aim of this study was to measure progression free survival (PFS) in advanced Hodgkin Lymphoma (HL) according to interim PET.

Methods: The international validation study IVS scope was to measure PFS in patients with stage IIB-IV HL according to PET-CT after 2 cycles of ABVD to determine if previous results (Gallamini et al JCO 2007) could be reproduced internationally involving patients from Europe, Australia and USA. PET-CT scans were collected retrospectively using WIDEN, checked for errors, transferred onto a WEB server (Keosys) and read remotely using identical software by 6 reviewers independently and blinded to clinical outcome. Interim scans were scored according to Deauville criteria. A score of 1-3 was regarded as ‘negative’(-ve) and 4 or 5 as ‘positive’(+ve).

Results: 261 paired scans were evaluated. In 253 patients the majority of the reviewers agreed that the PET was ‘positive’ or ‘neagtive’. The 8/261 patients in which there was a 3/3 disagreement were resolved in a consensus session. The concordance using a binary outcome (positive vs negative) was 0.758 using Krippendorf’s alpha. 218 patients (84%) were in CR and 43 patients (16%) progressed or relapsed with an average (median) FU of 38.3 (35.7) months. 46 patients were PET +ve and 215 were PET -ve. 32/46 PET +ve patients relapsed. 11/215 PET -v patients relapsed. The 3-year PFS of PET -ve and PET +ve patients was 95% and 30% respectively. The sensitivity and specificity for PFS were 0.74 and 0.94 and the PPV and NPV were 0.70 and 0.95 respectively.

Conclusions: The Deauville criteria using a cut off between 3 and 4 was reliable at discriminating patients with poor from good prognosis with high interobserver agreement in a multicentre study





This Article
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
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Google Scholar
Right arrow Articles by Kostakoglu, L.
Right arrow Articles by Gallamini, A.
PubMed
Right arrow Articles by Kostakoglu, L.
Right arrow Articles by Gallamini, A.