SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     




J Nucl Med. 2011; 52 (Supplement 1):595
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Rakheja, R.
Right arrow Articles by Hickeson, M.
PubMed
Right arrow Articles by Rakheja, R.
Right arrow Articles by Hickeson, M.

Oncology: Clinical Diagnosis: Sarcoma/Melanoma

Sarcoma/Melanoma

Metabolic activity measured by SUV from FDG-PET scans as a predictor of histopathologic characteristics: A retrospective review of 136 patients with sarcoma

Rajan Rakheja1, Ayoub Nahal1, Mathieu Charest1, Fadi Brimo1, Sonia Skamene1, Laurent Azoulay1, Jonathan Assayag1 and Marc Hickeson1

1 Nuclear Medicine, MUHC, Montreal, QC, Canada

Abstract No. 595

Objectives: Evaluate the correlation between metabolic activity of sarcomas and histopathological characteristics such as necrosis, mitotic count and a myxoid component.

Methods: We retrospectively evaluated 238 consecutive patients with known soft tissue or osseous sarcoma who had undergone a FDG PET/CT study for initial staging or recurrence of disease. The maximum standardized uptake value (SUVmax) of each primary and/or most intense metastatic lesion was measured and compared with histological data provided in final pathological reports.

Results: Histopathological data was available for 136 sarcomas (myxoid data for 2 patients, necrosis data for 3 patients and mitotic count data for 5 patients could not be retrieved). The median SUVmax for the sarcomas without myxoid component (118 patients) was 10.5 and with a myxoid component (16 patients) was 9.1 (p=0.28). The median SUVmax of the 90 sarcomas with necrosis on pathologic analysis was 11.3, as compared to 8.3 in 43 sarcomas without necrosis (p=0.026). Similarly, the median SUV max of sarcomas with mitotic counts of less than 2 (per 10 hpf), 2 to 7, 7 to 16.25, and greater than 16.25 were 5.7, 9.8, 12.1, and 13.1, respectively (p=0.0003).

Conclusions: There was no correlation between metabolic activity as defined by SUVmax and a myxoid component in the sarcoma. There was a statistically significant correlation between the presence of necrosis and a higher mitotic count and higher metabolic activity of the sarcoma on FDG-PET scan. This data suggest there may be a role for the future utilization of metabolic activity from FDG-PET scans in the grading/prognosis of sarcomas as well as for biopsy and treatment planning


Figure 01
View larger version (28K):
[in this window]
[in a new window]

 
Table 2. SUV* vs. Mitotic Counts (MC)

*Kruskal-Wallis Test for SUV,**p= 0.003

 




This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Rakheja, R.
Right arrow Articles by Hickeson, M.
PubMed
Right arrow Articles by Rakheja, R.
Right arrow Articles by Hickeson, M.