J Nucl Med. 2011; 52 (Supplement 1):595
Oncology: Clinical Diagnosis: Sarcoma/Melanoma
Metabolic activity measured by SUV from FDG-PET scans as a predictor of histopathologic characteristics: A retrospective review of 136 patients with sarcoma
Jonathan Assayag1 and
1 Nuclear Medicine, MUHC, Montreal, QC, Canada
Abstract No. 595
Objectives: Evaluate the correlation between metabolic activity of sarcomas and histopathological characteristics such as necrosis, mitotic count and a myxoid component.
Methods: We retrospectively evaluated 238 consecutive patients with known soft tissue or osseous sarcoma who had undergone a FDG PET/CT study for initial staging or recurrence of disease. The maximum standardized uptake value (SUVmax) of each primary and/or most intense metastatic lesion was measured and compared with histological data provided in final pathological reports.
Results: Histopathological data was available for 136 sarcomas (myxoid data for 2 patients, necrosis data for 3 patients and mitotic count data for 5 patients could not be retrieved). The median SUVmax for the sarcomas without myxoid component (118 patients) was 10.5 and with a myxoid component (16 patients) was 9.1 (p=0.28). The median SUVmax of the 90 sarcomas with necrosis on pathologic analysis was 11.3, as compared to 8.3 in 43 sarcomas without necrosis (p=0.026). Similarly, the median SUV max of sarcomas with mitotic counts of less than 2 (per 10 hpf), 2 to 7, 7 to 16.25, and greater than 16.25 were 5.7, 9.8, 12.1, and 13.1, respectively (p=0.0003).
Conclusions: There was no correlation between metabolic activity as defined by SUVmax and a myxoid component in the sarcoma. There was a statistically significant correlation between the presence of necrosis and a higher mitotic count and higher metabolic activity of the sarcoma on FDG-PET scan. This data suggest there may be a role for the future utilization of metabolic activity from FDG-PET scans in the grading/prognosis of sarcomas as well as for biopsy and treatment planning