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J Nucl Med. 2011; 52 (Supplement 1):310
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Oncology: Basic, Translational & Therapy: Basic Science

Basic Science IV (Oncology): Novel Image-Based Methods

PET tracer evaluation in the PAC120 human hormone-dependent prostate cancer xenograft rat model

Damaris Kukuk1, Hans Wehrl1, Olivier Raguin2, Andreas Schmid1, Julia Mannheim1, Gerald Reischl1 and Bernd Pichler1

1 Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany 2 Oncodesign, Dijon, France

Abstract No. 310

Objectives: The aim was to validate [11C]choline, [18F]FEC and [18F]FCh, three PET tracers specifically developed for prostate cancer imaging, and to compare them with [18F]FDG and [18F]FLT pre- and post-surgical castration in the PAC120 xenogeneic Nude rat model.

Methods: Dynamic and static "baseline" PET images of RH-rnu/rnu rats bearing subcutaneous human PAC120 tumors (mean tumor size 2217mm3, n=10) were acquired on five consecutive days. After "baseline" imaging, rats were surgically castrated and thereafter imaged again at two different time points. Tracer uptake was analyzed by acquiring time activity curves, standard uptake value and tumour-to-muscle-ratio (T/M). In addition we measured the apparent diffusion coefficient (ADC) and did chemical shift imaging of the PAC120 tumors on a 7T MRI scanner.

Results: The PET image analysis of the PAC120 tumors showed low "baseline" uptake of [18F]FLT (T/M: 1.14±0.16). [18F]FDG showed the highest uptake (T/M: 4.99±0.84) followed by [11C]choline (T/M: 2.19±0.32), [18F]FCh (T/M: 1.79±0.38) and [18F]FEC (T/M: 1.54±0.29). Nevertheless we found a significant decrease in the T/M ratio three weeks post-castration mainly with [18F]FDG (T/M: 2.96±0.64), [11C]choline (T/M: 1.31±0.23), [18F]FCh (T/M: 1.26±0.26) and [18F]FEC (T/M: 1.07±0.12). Analysis of the ADC maps revealed a clear increase of the diffusivity post-castration.

Conclusions: These data show for the first time a significant tumor response to androgen ablation therapy using PET imaging with [11C]choline and its derivates in an in vivo model of human hormone-dependent prostate cancer, xenografted in Nude rats. Most importantly, the same studies were previously performed in PAC120 tumor-bearing Nude mice without significant choline tracer uptake. This indicates strongly the species-dependency in prostate PET imaging. In conclusion, the PAC120 tumor-bearing Nude rat is a useful model to study new PET tracers for human prostate cancer diagnostics and therapy efficacy monitoring





This Article
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Right arrow Articles by Kukuk, D.
Right arrow Articles by Pichler, B.
PubMed
Right arrow Articles by Kukuk, D.
Right arrow Articles by Pichler, B.