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J Nucl Med. 2011; 52 (Supplement 1):2334
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Technologist Abstracts

Technologist Scientific Papers V

Optimal radiolabelling methods for Tc99m Sulfur Colloid oatmeal products for gastric emptying

Tory Maloy1, Manuel Herrera1, Mike Zimmer1 and Stewart Spies1

1 Nuclear Medicine, Northwestern Memorial Hospital, Chicago, IL

Abstract No. 2334

Objectives: The objectives were to determine the most effective radiolabelling method using Tc99m Sulfur Colloid(SC) and specific oatmeal products and to compare radiolabelled efficiency of oatmeal products to standard radiolabelled egg meal.

Methods: Two specific oatmeal products were evaluated: instant oatmeal and gluten-free oatmeal. For each specific oatmeal product, Tc99m SC(1200µCi)was added either prior to or after addition of boiling water(75ml). Following labelling, three alliquots from each specific product were removed into conical test tubes, 45-ml H2O added and shaken. Separation of specific radiolabelled oatmeal product and unbound Tc99m SC was achieved by low speed centrifugation(2000rpm) for 2 minutes. Following separation, the activity of radiolabelled oatmeal and supernatant was determined using a dose calibrator(Biodex Atomlab100). For comparison, eggs were radiolabelled as described above. For each specific product evaluated, the mean percent labelling was determined. Results were compared to the percent labelling with standard egg meal.

Results: For instant oatmeal and gluten-free oatmeal the mean percent radiolabelled product when Tc99m SC was added prior to boiling H2O was 87% and 86%, respectively. When Tc99m SC was added after boiling H2O, the mean percent radiolabelled product was reduced to 67% and 62%, respectively. The mean labelling efficiency of radiolabelled egg was 86%. The labelling technique in which Tc99m SC was added to oatmeal products prior to boiling H2O provides a labelling efficiency comparable to standard egg meal.

Conclusions: The most effective way of radiolabelling oatmeal was adding Tc99m SC prior to addition of boiling H2O. Radiolabelling results were comparable to those achieved with radiolabelled egg meal





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Spies, S.
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Right arrow Articles by Maloy, T.
Right arrow Articles by Spies, S.