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J Nucl Med. 2010; 51 (Supplement 2):387
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Neurosciences: Neurology

Neurology: Dementia - Amyloid Imaging

Florbetapir (18F-AV-45) PET imaging of β-amyloid plaques is highly correlated with histopathological assays at autopsy

Mark Mintun1, Krishnendu Saha2, Adam Fleisher3, Julie Schneider4, Thomas Beach5, Barry Bedell6, Christopher Clark7, Michael Pontecorvo2 and Daniel Skovronsky2

1 Washington University, St. Louis, MO 2 Avid Radiopharmaceuticals, Philadelphia, PA 3 Banner Alzheimer's Institute, Phoenix, AZ 4 Rush University, Chicago, IL 5 Sun Health Research Institute, Sun City, AZ 6 Biospective Inc, Montreal, QC, Canada 7 University of Pennsylvania, Philadelphia, PA

Abstract No. 387

Objectives: A quantitative PET tracer to image amyloid deposition, validated to pathological assays, could improve diagnosis and management of dementing disorders.

Methods: Six subjects (ages 45-86 yrs) with a life expectancy < 6 months underwent a 10 min PET scan 50 min after iv injection of 10 mCi of florbetapir. Images were rated visually (0 - 4 scale) for global and regional cortical uptake. Regional standard uptake values ratios (SUVr) were also determined. After death (mean interval after imaging 43 days) brain sections matching six PET regions were evaluated for density of β-amyloid deposition using immunohistochemistry (IHC) and plaque counting.

Results: The florbetapir PET images were correlated with mean tissue β-amyloid IHC by visual rating (rs=0.88, p<0.01) and mean SUVr (r=0.89, p<0.01) and to mean plaque counts by visual rating (rs=0.80, p<0.02) and mean SUVr (r=0.78, p<0.05). Regional analyses also showed significant correlations (Table 1).

Conclusions: Florbetapir PET brain images are highly correlated with autopsy-confirmed β-amyloid deposition and thus are likely to have utility in the evaluation of patients with suspected dementia


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Table 1. Correlation Coefficients ( r )

 




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