SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):93P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Pandey, U.
Right arrow Articles by Pillai, M.
PubMed
Right arrow Articles by Pandey, U.
Right arrow Articles by Pillai, M.

Radiopharmaceutical Chemistry: Radiopharmacy

Radiopharmacy I

Validation of ‘BARC Technique’ for estimation of the radionuclidic purity of 90Y and measurement of 90Sr in 90Y prepared by different 90Sr/90Y generators

Usha Pandey2, Rubel Chakravarty2, Prem Dhami3, Meera Venkatesh2 and Maroor Pillai1

1 NAPC, IAEA, Vienna, Austria; 2 Radiopharmaceuticals Division; 3 Fuel Reprocessing Division, Bhabha Atomic Research Centre, Mumbai, India

371

Objectives: A technique based on extraction paper chromatography (EPC, developed at the Bhabha Atomic Research Centre (BARC), is capable of accurately measuring <10-4% 90Sr in 90Y, by chelating it with a specific ligand, KSM-17. In PC, 90Sr alone moves to the solvent front, and is quantified by liquid scintillation counting. Our aim was to validate this technique and analyze 90Y obtained from different 90Sr/90Y generators.

Methods: 5µL (37 MBq/mL) of different samples of 90Y containing various amounts 90Sr was applied on a Whatman 1 chromatography paper impregnated with 10µl of 2-ethyl hexyl, 2-ethyl hexyl phosphonic acid (KSM-17) at the point of application. The paper was developed in saline, dried, cut into 0.5 cm pieces and counted in a liquid scintillation counter(LSC). Blank measurements were carried out to see the effect of paper in counting. EPC technique was validated by measuring the 90Sr and 90Y levels in decayed 90Y samples (>2months decay). EPC method was used to determine the 90Sr contamination in 90Y eluted from a two stage supported liquid membrane based generator as well as an electrochemical generator.

Results: The 90Sr estimated by EPC matched very well with the long decay measurements. The paper did not affect the count rate in LSC. EPC analysis of 90Y from the SLM and electrochemical generator showed that 90Sr levels are below the allowed limits (<74kBq in 3.7 GBq of 90Y.)

Conclusions: The ‘BARC technique’ for estimation of 90Sr is reliable, sensitive and can be utilized for real time regular QC analysis of 90Y used for targeted therapy.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Pandey, U.
Right arrow Articles by Pillai, M.
PubMed
Right arrow Articles by Pandey, U.
Right arrow Articles by Pillai, M.