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J Nucl Med. 2008; 49 (Supplement 1):91P
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General Clinical Specialties: Pulmonary

PET, Ventilation-Perfusion

Combined 18F-FDG-PET/CT appearances in pulmonary fibrosis: First experience

Ashley Groves1, Thida Win2, Nicholas Screaton3, Marko Berovic1, Raymondo Endozo1, Heidi Batchelor1, Irfan Kayani1, Manu Shastry1, John Dickson1 and Peter Ell1

1 Institute of Nuclear Medicine, UCL, London, United Kingdom; 2 Chest Medicine, Lister Hospital, Stevenage, United Kingdom; 3 Radiology, Papworth Hospital, Cambridge, United Kingdom

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Objectives: To describe our first combined 18F-FDG-PET/CT experience in patients with pulmonary fibrosis.

Methods: 17 consecutive patients (15 male, 2 female, mean age 66.6 +/-11.1 years) with newly diagnosed pulmonary fibrosis were recruited for 18F-FDG-PET/CT. The pattern distribution of pulmonary uptake was recorded and comparison was made between patients with typical idiopathic pulmonary fibrosis (Usual Interstitial Pneumonitis/ UIP) and those without. 18FDG uptake in mediastinal lymph nodes was also assessed.

Results: 9/17 patients had typical findings of idiopathic pulmonary fibrosis while in 8 patients CT findings were atypical for UIP. There was raised pulmonary 18FDG uptake in all patients. In all patients the maximum 18FDG uptake was peripherally in the basal aspect of the lower-lobes. The mean SUVmax to background (normal lung) ratio (TBR) = 4.0 (range= 2.2-6.8). The mediastinal nodal mean SUVmax was 2.62 (range 0- 4.9) with an SUVmax >3.0. in 5 patients. The mean SUVmax to TBR in patients with typical idiopathic pulmonary fibrosis =3.58 +/- 0.78 and for the other patients= 4.49 +/- 1.54 (t-test, P=0.138).

Conclusions: Pulmonary18FDG uptake was raised in all patients presenting with newly diagnosed pulmonary fibrosis. The pattern of 18FDG uptake was similar in all patients, with a peripheral basal distribution. 18FDG uptake was lower in patients with typical CT features of idiopathic pulmonary fibrosis compared to those with atypical features, but the difference was not statistically significant. Raised mediastinal lymph node 18FDG uptake was a frequent finding.

Research Support: The Royal College of Radiologists part-funded this work.





This Article
Services
Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Groves, A.
Right arrow Articles by Ell, P.
PubMed
Right arrow Articles by Groves, A.
Right arrow Articles by Ell, P.