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Half-time SPECT acquisition with resolution recovery for Tc-MIBI SPECT/CT – "Evolution for parathyroid"

¹ Rambam Health Care Campus, Haifa, Israel

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Objectives: Tc-MIBI SPECT/CT is of value for diagnosis and localization of parathyroid adenoma (PTA), in particular prior to minimally invasive or re-exploratory surgery. Present study assesses image quality and diagnostic accuracy of half-time SPECT acquisition with collimator-detector response compensation reconstruction for parathyroid SPECT/CT.

Methods: Twenty-five consecutive patients (pts) with suspected hyperparathyroidism (M=8, age 22-74) performed scintigraphy following the administration of 20 mCi Tc-MIBI in search of PTA. "H"mode, 360 degree rotation SPECT was performed sequentially at 30 min after injection using standard (36sec/frame, 18 min total time) and half–time "Evolution" (18sec/frame, 9 min total time) protocols, followed by 4 min low-dose multislice CT (Infinia Hawkeye-4, GE Healthcare). A total of 50 SPECT studies reconstructed using standard and resolution recovery methods respectively, were randomly reviewed, analyzed and compared visually for detectability of MIBI-avid foci and lesion contrast.

Results: SPECT/CT was negative in 5 pts, identified a PTA in 17 pts (3 ectopic) and an intra-thyroidal lesion in 3 pts. There was no difference in the detectability rate of MIBI-avid foci between the 2 SPECT protocols. All lesions showed similar non-compromised contrast resolution and target/background on both SPECT data sets.

Conclusions: A significant reduction in acquisition time of Tc-MIBI SPECT associated with corrective resolution recovery reconstruction can be successfully implemented in SPECT/CT for parathyroid. Diagnosis and preoperative localization of small lesions is obtained without compromising clinically significant information, in addition to improved patient compliance, less potential misregistration due to involuntary movement and increased patient throughput.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Israel, O. Articles by Keidar, Z. PubMed Articles by Israel, O. Articles by Keidar, Z.