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J Nucl Med. 2008; 49 (Supplement 1):85P
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General Clinical Specialties: Pediatrics

Pediatrics

Initial experience with weight-based, low-dose pediatric PET/CT protocols

Adam Alessio1, Vivek Manchanda2, Paul Kinahan1, Victor Ghioni2, Lisa Aldape2, Joshua Busch1 and Marguerite Parisi2

1 Radiology, University of Washington, Seattle, Washington; 2 Radiology, Seattle Children's Hospital, Seattle, Washington


Formula

338

Objectives: To develop pediatric PET/CT acquisition protocols customized to patient weight and estimate the dosimetry of these low-dose protocols.

Methods: FDG-PET CT scans were performed on 45 patients weighing 9.2-109kg (aged 1.4-23 years). These patients were scanned first in PET mode with a weight-based injected activity (0.144mCi/kg, 1mCi minimum/10mCi maximum) and acquisition times (3-5 min/FOV) and then received a CT for attenuation correction (CTAC, 120kVp) with a weight-based tube current ranging from 10-40mAs. Patients were categorized based on the Braslow color-coded weight scale with 11 categories defining different acquisition settings. Dosimetry for the PET and CTAC acquisition in each category was derived from mean patient sizes and the interpolation of scaling terms for accepted 1,5, 10, 15 year old, and adult models.

Results: Whole-body PET/CT acquisitions using the proposed weight-based protocols result in an approximate total effective dose of 5.4mSv for 9 kg 70cm patient up to 10.0 mSv for a 70kg 170cm patient. The effective dose from the proposed CTAC was on average a factor a 3.4 less than a conventional diagnostic abdomen CT and was on average 25% of the total dose from the entire PET/CT exam. Qualitative review of these exams revealed that all CTAC’s performed were acceptable to perform PET localization and serve as an anatomical reference.

Conclusions: Low-dose PET/CT protocols for 11 patient weight categories were developed and implemented in our clinic. The use of 11 categories as opposed to fewer categories allows for refinement of maximum CTAC tube current to minimize dose while maintaining image quality. Future effort will determine optimal PET acquisition durations and further refine CT tube voltage and current for each category.





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Alessio, A.
Right arrow Articles by Parisi, M.
PubMed
Right arrow Articles by Alessio, A.
Right arrow Articles by Parisi, M.