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General Clinical Specialties: PediatricsPediatrics |
1 Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
334
Objectives: The purpose of this study was to evaluate the roles of FDG PET CT and skeletal scintigraphy in the management of children, adolescents, and young adult patients with Hodgkin lymphoma.
Methods: 18 patients aged 7 -24 years with HL lymphoma were the subjects of this study. Each received bone scanning and FDG PET CT for clinical purposes within 2 weeks of each other. Eleven patients were first studied at the time of disease presentation and 7 at the time of known or suspected relapse. There were 38 scan pairs in total.
Results: Six patients (9 scan pairs) had disease demonstrated on both scans. In 4 patients (5 scan pairs), FDG PET CT showed involvement that was not evident on bone scanning. In 2 patients (2 scan pairs), the FDG PET scan was considered equivocal while the bone scan was negative. In 2 more patients (2 scan pairs), FDG PET CT showed involvement while the bone scan was considered equivocal. In one patient (one scan pair), bone scanning showed abnormal uptake in a benign lesion. In 9 patients (19 scan pairs), neither study showed bone involvement.
Conclusions: All sites of osseous involvement identified on skeletal scintigraphy were present on FDG PET CT scanning. Many additional sites of bone metastases were identified on FDG PET CT scanning. Since FDG PET CT detects both osseous and non osseous lesions, FDG PET CT is the functional imaging method of choice to evaluate patients with Hodgkin lymphoma for bone involvement. The bone scan may be safely eliminated, resulting in cost savings and reduction in radiation exposure
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