HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Hattori, N. Articles by Lewis, D. PubMed Articles by Hattori, N. Articles by Lewis, D.

Cognitive fatigue with mild traumatic brain injury (MTBI) may indicate fronto-cerebellar functional dissociation

¹ Radiology, Nuclear Medicine, University of Washington, Seattle, Washington; ² Psychology, Seattle Pacific University, Seattle, Washington; ³ Neurology, Minor and James Medical, Seattle, Washington; ⁴ Neuropsychology, VA Puget Sound Health Care System, Seattle, Washington; ⁵ Nuclear Medicine, Seattle Nuclear Medicine, Seattle, Washington

331

Objectives: MTBI patients with cognitive fatigue may show a different response to Paced Auditory Serial Addition Task (PASAT). Objective was to investigate activated regions and its correlation with test performance.

Methods: Fifteen chronic MTBI patients, (12 women, 45±11years), and 15 healthy control (HC:12 women, 43±9 years) underwent 2 SPECT scans using Tc-99m ECD at rest and during activation with PASAT, a measure of divided attention and processing speed. Following image registration and normalization, pair-wise subtractions were conducted between resting and activated scans and averaged across participants. The result was correlated with the PASAT score using 3D-SSP.

Results: PASAT activated bilateral insula, medial frontal cortex and cerebellum in HC. MTBI showed a weaker and larger activation in bilateral insula and frontal cortex, and less activation in cerebellum.In HC, PASAT scores correlated with bilateral cerebellar (R =0.98, Z-score = 3.43) and left superior frontal (R= 0.93, Z-score = 2.66) activations. In MTBI, it correlated with left superior frontal activation (R =0.96, Z-score = 3.03), but did not correlate with cerebellar activation.

Conclusions: Activation in cerebellum and left superior frontal cortex positively correlated with PASAT score in HC. MTBI shows less activation / no correlation in cerebellum although left superior frontal cortex demonstrated a positive correlation. In conclusion, MTBI with cognitive fatigue may suffer fronto-cerebellar functional dissociation to respond paced information.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Hattori, N. Articles by Lewis, D. PubMed Articles by Hattori, N. Articles by Lewis, D.