J Nucl Med. 2008; 49 (Supplement 1):75P
Cardiovascular: Clinical ScienceUpdate on Cardiac PET |
Measurement of coronary endothelial function with Rubidium-82 PET – Comparison with oxygen 15-labeled water PET
Keiichiro Yoshinaga1,
Osamu Manabe2,
Chietsugu Katoh2,
Masanao Naya2,
Robert deKemp3,
Ran Klein3,
Rob Beanlands3 and
Nagara Tamaki2
1 Molecular Imaging;
2 Nuclear Medicine, Hokkaido University, Sapporo, Japan;
3 Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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Objectives: We have evaluated coronary endothelial function in smokers using O-15 water. While this method is considered ideal for myocardial blood flow (MBF), it has limited clinical use. MBF with Rb-82 has great potential in the assessment of coronary endothelial function for widespread clinical use. We evaluated MBF responses during hyperemia and cold pressor test (CPT) in smokers using Rb-82 and compared to O-15 water.
Methods: In 10 controls (age 38±12 y) and 10 smokers (52±9 y, P<0.01), MBF was assessed at rest, hyperemia, and CPT with Rb-82 and O-15 water. A one-compartment model was used to estimate MBF with both tracers. MBF was corrected for rate-pressure product.
Results: MBF increased during hyperemia compared to rest for both tracers (P<0.01). CFR with O-15 water in controls was higher than smokers (P<0.01). There was no difference in CFR with Rb-82. For both approaches, controls had increased MBF during CPT compared to rest (P<0.01) but smokers did not. CPT reserve was reduced in smokers with either method (P<0.05). Flow measurements were well correlated over a wide flow range for the tracers (r=0.79;p<0.01).
Conclusions: Rb-82 and O-15 water flow estimates are well correlated and both identified altered flow response during CPT in smokers. Rb-82 has a potential for wide clinical application including the measurement of coronary endothelial function in smokers.
