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J Nucl Med. 2008; 49 (Supplement 1):72P
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Cardiovascular: Clinical Science

New Software, Hardware and Tracer Development II

New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT

Ines Valenta1, Valerie Treyer1, Lars Husmann1, Oliver Gaemperli1, Michael Schindler1, Patrick Veit-Haibach1, Klaus Strobel1, Fuminari Tatsugami1 and Philipp Kaufmann1

1 Nuclear Cardiology, University Hospital Zurich, Zurich, Switzerland

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Objectives: The purpose of this study was to evaluate a new iterative reconstruction algorithm for SPECT MPI allowing shortened acquisition time (HALF) while maintaining image quality.

Methods: 50 patients, referred for evaluation of known or suspected coronary artery disease by MPI and SPECT using 99mTc-Tetrofosmin underwent one day adenosine stress 300 MBq / rest 900 MBq protocol with standard FULL time (stress/rest 15 min) immediately followed by short emission scan (stress/rest 9/7min) on a Ventry SPECT camera (GE Healthcare). Full time scans were reconstructed iteratively with the software "Myovation" (GE Healthcare), short scans were additionally processed with a recently developed software algorithm for half time emission scans (Evolution for Cardiac, GE Healthcare). All reconstructions were subsequently analyzed using commercially available software (QPS/QGS, Cedars Medical Sinai) with/without X-ray based attenuation correction (AC). Regression analysis and Bland-Altman (BA) limits of agreement were used to compare uptake values (percent of max) HALF vs FULL in 20 segments.

Results: There was 98% clinical agreement between HALF and FULL analysis and an excellent correlation for uptake in each segment (n=1000) at rest (r=0.89, p<0.001) and at stress (r=0.87, p<0.001). The respective BA limits of agreement were -11 to 10 % and -12 to 11 %. After AC similar correlation (r=0.82, rest; r=0.80, both p<0.001) and BA limits were found (-12 to 10; -13 to 12).

Conclusions: With the new algorithm "Evolution for Cardiac" MPI can be acquired with half of the scan time without compromising image quality, resulting in an excellent agreement with regard to uptake and clinical conclusion.





This Article
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Right arrow Email this article to a friend
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Right arrow Articles by Valenta, I.
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Right arrow Articles by Valenta, I.
Right arrow Articles by Kaufmann, P.