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J Nucl Med. 2008; 49 (Supplement 1):68P
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Novel Approaches to Molecular Imaging

PET/MRI, MRI and Ultrasound

Animal PET/MRI: Simultaneous imaging of complimentary multi-functional and morphological information in mouse models

Martin Judenhofer1, Hans Wehrl1, Konrad Lankes1, Stefan Wiehr1, Gerald Reischl1, Hans-Juergen Machulla1, Claus Claussen1 and Bernd Pichler1

1 Department of Radiology, University of Tuebingen, Tuebingen, Germany

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Objectives: A PET scanner was developed which operates without mutual interference in a 7T animal MRI. Animal studies in the field of oncology, neurology, and cardiology show the potential of simultaneous PET/MR imaging.

Methods: The MR compatible PET detector has a combined PET/MR field of view of 35mm in transaxial and 19mm in axial direction. Evaluations of the combined PET/MRI system showed that the imaging performance of both systems is maintained. Tumor mice were imaged using co-injections of [18F]FLT or [18F]FDG and gadolinium MR contrast agents (CA) to analyze the complimentary dynamic information revealed by the tracers and contrast agent. In neurology, studies focused on comparative perfusion measurements using [15O]water and MR contrast agents.

Results: The imaging studies performed with the CT26-tumor mice revealed at areas with low [18F]FLT uptake a slow and shallow enrichment of MR CA, whereas tumor regions with high [18F]FLT uptake corresponded to a fast and high MR CA enrichment. The complimentary information of PET and MRI, acquired simultaneously with a spatial fusing accuracy of better than 0.5 mm, allowed the distinction of necrotic and high proliferation tumor areas. The in vivo results were confirmed by histology. The brain studies delivered comparable results for the perfusion measured by either [15O]water or gadolinium MRI. ECG gated PET/MRI allowed an exact spatial and temporal co-registration of [18F]FDG-PET images and the MR morphology.

Conclusions: Imaging studies with the animal models showed the diagnostic value of acquiring simultaneous multi-functional and morphological information. In cardiology we see an advantage of PET/MRI by using the simultaneous acquired information for motion correction.

Research Support: NIH





This Article
Services
Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Judenhofer, M.
Right arrow Articles by Pichler, B.
PubMed
Right arrow Articles by Judenhofer, M.
Right arrow Articles by Pichler, B.