| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
|
|
|||||||||
|
|
Oncology-Clinical Diagnosis: Solid TumorsLung Cancer II |
1 Research Institute & Hospital, National Cancer Center, Korea, Goyang, Gyeonggi-do, South Korea
222
Objectives: FDG PET/CT has been valuable staging work-up in lung cancer. FDG PET showed good diagnostic efficacy in most lung cancer, but the imaging characteristics seemed to be somewhat different in terms of their histologic types such as squamous cell carcinoma and adenocarcinoma. The aim of this study is to describe the difference of nodal FDG accumulation and characteristics.
Methods: 117 lung cancer patients were enrolled prospectively from 1st Oct. 2006 to 31st Oct. 2007, who had been proven with aspiration and/or biopsy. FDG PET/CT was performed and followed by endobronchial ultrasonographic biopsy and operation.
Results: Primary FDG accumulation was 10.5 ±3.9 in SCC and 6.58 ±4.0 in ADC (p<0.05). Nodal FDG accumulation was different between SCC (n=53) and ADC (n=55) (10.64±4.3 vs. 6.4±4.3g/ml, p < 0.05). Short diameter was not different (8.9±2.7 vs. 8.0±2.6mm). In SCC, SUV showed better diagnostic performance in 3.14 g/ml (sen 100%, spe 87.9, AUC 9.63) than short diameter did in 9 mm (sen 85.7%, spe 63.8%, AUC 0.813) using receiver operating characteristic curve. In ADC, the performance was not different between SUV (cut-off 3.02 g/ml, sen 56%, spe 82.4%, AUC 0.763) and short diameter (cut-off 9.1 mm, sen 64%, spe 89.3%, AUC 0.804).
Conclusions: Diagnostic performance of FDG PET/CT is different according to the histologic type in nodal staging. FDG PET/CT was more accurate in SCC than in ADC.
Research Support: This study was supported by National Cancer Center Grant 710620.
| ||||||||||||||||||||||||||||||||||||||
