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Technologist AbstractsTechnologist Posters |
1 Dept Radiation Oncology, U of Toronto, Toronto, Ontario, Canada
2122
Objectives: To investigate changes in SUV on FDG PET scans due to effects of both radiation treatment (RT) and uptake time in patients with non-small-cell lung cancer.
Methods: Scans were acquired twice on the same patient and same day, once for whole lung (WL) in RT planning position and once for whole body (WB) imaging in 25 pre-RT patients. 17 of these patients had 2nd scans during RT with two scans being performed; the same WL and a gated PET, 11 of these had 3rd scans performed 8 weeks after RT with the same two scans as pre-RT scans. All scans were acquired and reconstructed with same parameters. Volumes of interest were manually placed on images of the primary lung tumor to determine maximum SUV. Paired SUVs for each day were compared with a Wilcoxon signed rank test.
Results: The overall mean (m) and range (r) of SUV and time (T) in min of uptake (between injection and scan) are as follows:
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The range of SUVs for three paired scans decreased during- and post-RT as compared to pre-RT scans. Wilcoxon tests demonstrated that paired SUVs were significantly different (p<0.00005) in pre-RT scans, not different (p=0.76) during- and only slightly different (p<0.04) in post-RT scans. These small differences in paired SUVs for post-RT scans however are in the order of the uncertainty of the measurements.
Conclusions: In this study, SUV changed with both RT and uptake time. Compared with the pre-RT scans, the effect of different uptake times on SUV was reduced during and after RT, indicating that the uptake time is less important during and after RT.
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