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J Nucl Med. 2008; 49 (Supplement 1):417P
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Technologist Abstracts

Technologist Papers III

Performance comparison of high-resolution pinhole SPECT for small animal imaging using two conventional SPECT systems

Byungho An1, Byungjun Min2, Junsang Bae2, Yong Choi2, KyungHan Lee2 and Byung-Tae Kim2

1 Dept. Nuclear Medicine, Samsung Medical Center, The Korean Society of Nuclear Medicine Technology, Seoul, South Korea; 2 Dept. Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

2018

Objectives: Conventional SPECT systems with pinhole collimator offer a high spatial resolution. However, typical pinhole collimator is not suitable for small animal imaging. Our goal is to design a high-resolution pinhole collimator and to compare the performance of high-resolution pinhole SPECT for small animal imaging using these systems.

Methods: In this study, 4 mm and 2 mm diameter pinhole collimators were mounted on a single head Trionix MONAD and Siemens E.CAM SPECT systems. Two mm diameter pinhole collimator was fabricated for high-resolution SPECT imaging. Micro Deluxe phantom was used for performance comparison. Small animal imaging was performed using normal and myocardial infarction model of rat. Tl-201 and Tc-99m MIBI were used for myocardial imaging. Center of rotation correction for SPECT imaging was implemented using point source. Tmages were reconstructed using OSEM algorithm.

Results: Using both systems, down to 3.2 mm and 2.4 mm rods were resolved with 4 mm and 2 mm diameter pinhole collimators in Micro Deluxe phantom, respectively. In myocardial perfusion imaging, myocardial walls were clearly discernible using both systems. Moreover, perfusion defect of myocardium was clearly visible. Although two systems show compatible image quality, the sensitivity of Siemens E.CAM SPECT system is 2-fold higher than that of Trionix MONAD SPECT system.

Conclusions: Cost effective small animal imaging systems with conventional SPECT systems were developed and compared using fabricated 2 mm pinhole collimator. These systems can be employed for quantitation of biological function such as myocardial perfusion imaging for small animals.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by An, B.
Right arrow Articles by Kim, B.-T.
PubMed
Right arrow Articles by An, B.
Right arrow Articles by Kim, B.-T.