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J Nucl Med. 2008; 49 (Supplement 1):415P
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Technologist Abstracts

Technologist Papers II

Comparison of image reconstruction methods in estimating of human neuroreceptor binding with PET

Takahiro Shiraishi1, Hiroshi Ito1, Fumitoshi Kodaka1, Katsuyuki Tanimoto1, Toshio Miyamoto1, Hiroki Fukuda2, Yasushi Isahai2, Tetsuya Suhara1, Katsuhide Ito3 and Kazuhiro Watanabe1

1 National Institute of Radiological Sciences, Chiba, Japan; 2 Association for Nuclear Technology in Medicine, Tokyo, Japan; 3 Hiroshima University, Hiroshima, Japan

2012

Objectives: FBP is a standard method for quantitative analysis in human neuroreceptor binding assay, while OSEM is used widely in tumor PET imaging. Owing to noise propagation from projection data, especially at high subset number, OSEM leads to loss of signal to noise (SNR) and quantitative accuracy. A novel reconstruction algorithm DRAMA can suppress the noise propagation by using dynamic relaxation parameter with faster convergence compared to OSEM algorithm. In this study, we compared regional radioactivity concentrations and binding potential (BP) values between FBP, OSEM and DRAMA to assess the effect of DRAMA algorithm on estimating human nuroreceptor binding.

Methods: The PET scanning was carried out with Shimadzu Eminence STARGATE. After 4min pre-injection transmission scan, [11C] FLB457, 90min dynamic PET scans were performed with 3D. To compare reconstruction parameter, a phantom scan was done with same scan protocol. Images were reconstructed with FBP, OSEM and DRAMA to assess quantitative accuracy and noise characteristics.

Results: In phantom study, SNR of DRAMA was improved 31% compared to FBP with similar quantitative accuracy. In patient study, the difference of BP by OSEM with iteration 4, subset 8 compared to FBP was -1.35% at maximum in the caudate, while that of DRAMA was +0.08%.

Conclusions: There were no significant difference of BP values in caudate, putamen and thalamus between DRAMA and FBP. Furthermore, noise propagation was not shown in DRAMA. These results indicated that DRAMA could provide similar performance of FBP with the improved SNR, therefore, DRAMA can be a novel standard reconstruction method of neuroreceptor PET studies.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Shiraishi, T.
Right arrow Articles by Watanabe, K.
PubMed
Right arrow Articles by Shiraishi, T.
Right arrow Articles by Watanabe, K.