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J Nucl Med. 2008; 49 (Supplement 1):413P
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Technologist Abstracts

Technologist Papers I

Single time-point planar and SPECT/CT 111-In pentetreotide scintigraphy: Does it have advantages over dual time-point planar and SPECT imaging?

Elizabeth Wynn1, Robert Ackermann1, John Cahill1, Kirk Frey1, Anca Avram1 and Ka Kit Wong1

1 Nuclear Medicine, University of Michigan, Ann Arbor, Michigan

2003

Objectives: To assess advantages of single time-point 24 hours (h) planar and SPECT/CT imaging over dual time-point (24h planar and SPECT + 48h planar imaging) in 111-In pentetreotide imaging of neuroendocrine tumors (NET).

Methods: Twenty-four patients (9 M,15 F; mean age: 56 y, range: 14-82) with carcinoid (n=16), gastrointestinal NET (n=6) or MEN type 1 (n=2) underwent 111-In pentreotide imaging. Two blinded readers independently interpreted dual time-point images(24h + 48h planar and 24h SPECT), and subsequently single time-point images(24h planar and SPECT/CT). Studies were classified as normal or abnormal, all abdominal structures were assessed, and interpretations compared to the final report based on 24h + 48h planar and 24h SPECT/CT.

Results: Agreement with the final report for dual time-point imaging occurred in 23/24 (95.8%) studies for Reader 1 and in 17/24 (70.8%) for Reader 2. Agreement for single time-point imaging occurred in 22/24 (91.7%) studies for Reader 1 and in 24/24 (100%) for Reader 2. After review of 24h planar + SPECT data, delayed 48h planar imaging was considered necessary in 22/24 (91.7%) studies for Reader 1, and in 13/24 (54%) for Reader 2. However, after review of 24h SPECT/CT data, Reader 1 requested delayed 48h planar imaging in 3/24 and Reader 2 in 1/24 studies.

Conclusions: SPECT/CT allows accurate diagnosis of tumor versus physiologic activity in normal abdominal structures. Addition of SPECT/CT to planar imaging at 24h allows single time-point imaging, making the study more convenient for the patient and improving imaging efficiency. Dual time-point imaging may still be performed in selected cases for diagnostic problem solving.





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Right arrow Articles by Wong, K. K.