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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Yamamoto, S. Articles by Hatazawa, J. PubMed Articles by Yamamoto, S. Articles by Hatazawa, J.

Development of a high sensitivity BGO well counter for small animal PET researches

¹ Kobe City College of Technology, Kobe, Japan; ² Osaka University Graduate School of Medicine, Osaka, Japan

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Objectives: In quantitative measurements of small animal PET studies, blood sampling volume is limited because of the limited amount of blood of small animals. In addition, injection dose for small animal PET study is also limited. In these situations, high sensitivity well counter will be useful to reduce the amount of blood sampling from small animals. BGO has high stopping power for high energy gamma than NaI(Tl) that is commonly used for conventional well counter. We developed a BGO well counter and tested for a high sensitivity blood sampling system.

Methods: The BGO well counter used a square BGO block (59mmx59mmx50mm) which has a square open space (27mmx27mmx34mm) in the central part of the block. The BGO block was optically coupled to a 60mm square photo-multiplier tube (PMT) and contained in a led shield. Signal from the PMT was digitally processed for such as integration and energy window. Performance of the BGO well counter was measured and compared with that of a 2-inch round NaI(Tl) well counter.

Results: Energy spectrum of the BGO well counter measured with Na-22 point source showed about 6 times higher counts on the 1022-keV (511-keV x 2) gamma peak than that of NaI(Tl). Relative sensitivity of the developed BGO well counter for both energy peak was 3.4 times higher than 2-inch NaI(Tl) well counter with manufacture’s recommended energy window. Artery time activity curve was successfully obtained using the BGO well counter for rat FDG study.

Conclusions: Developed BGO well counter will contribute to reduce amount of sampling blood or to improve the throughput of quantitative measurements of the small animal PET studies.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Yamamoto, S. Articles by Hatazawa, J. PubMed Articles by Yamamoto, S. Articles by Hatazawa, J.