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Performance characteristics of a high-sensitivity small animal DOI-PET scanner with a large axial FOV: ClairvivoPET

¹ Shimadzu Corporation, Kyoto, Japan

1696

Objectives: Newly developed small animal PET scanner, ClairvivoPET, would allow superior kinetic imaging with fast physiological responses by taking advantage of high sensitivity, large axial FOV with DOI detectors. In this study we investigated the usefulness in kinetic imaging through some performance tests and whole-body mouse dynamic studies.

Methods: This scanner consists of two-layer LYSO DOI detector modules with its total thickness of 15 mm, and has 100 mm diameter of transaxial FOV and 151 mm extent of axial FOV. Spatial resolution, sensitivity, NEC rates, and quantitative accuracy against activity strength were measured and evaluated. Tumor implanted mouse at lower extremities injected with 4 MBq of 18F-D-FMT was acquired for 60 minutes in list-mode format and were reconstructed as dynamic images.

Results: Transaxial and axial resolutions measured with a capillary tube were 1.54 mm and 1.46 mm at the center, and 2.93 mm and 1.76 mm at radial offset of 40 mm in FWHM respectively. Absolute sensitivity measured at the condition of 350-750 keV energy window was 8.2 % at the center. Peak NEC rates for mouse- and rat-sized uniform cylindrical phantoms were 232 kcps at 173 kBq/ml and 87 kcps at 49 kBq/ml. The quantitative accuracy against activity concentration was within 2 % over 5 half-lives, ranging from 1kBq/ml to 50 kBq/ml. From the whole-body mouse dynamic image acquired without a bed movement, simultaneous time activity curves at the cardiac pool and the tumor could be extracted clearly even in short time interval.

Conclusions: ClairvivoPET, which has well-balanced performances with DOI detectors, was considered to be useful especially in whole-body mouse kinetic imaging with fast physiological responses and is expected to contribute in new drug development and in molecular imaging.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Mizuta, T. Articles by Inoue, Y. PubMed Articles by Mizuta, T. Articles by Inoue, Y.