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J Nucl Med. 2008; 49 (Supplement 1):402P
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Instrumentation & Data Analysis: Instrumentation

Instrumentation Posters

Comparative simulation study of count rate characteristics for I-124 and F-18 on the micro PET R4

Jin Su Kim1, Kyeong Min Kim1, Sang Keun Woo1, Jong-Guk Kim1, Jae Sung Lee2, Dong Soo Lee2, Gi Jeong Cheon1, Chang Woon Choi1 and Sang Moo Lim1

1 Division of Nuclear Medicine and RI Application, KIRAMS, Seoul, South Korea; 2 Department of Nuclear Medicine, Seoul National University, Seoul, South Korea

1695

Objectives: I-124 is an isotope suitable for development of new radiopharmaceutical and immuno-PET. The physical characteristics of I-124 induce the degradation of image quality. In this study, we compared the physical characteristics of I-124 with those of F-18, using computer simulation, to find optimal acquisition protocol in I-124 PET.

Methods: Monte Carlo simulation to measure sensitivity, scatter fraction (SF) and NECR were done on the microPET R4 scanner for both of I-124 and F-18 with energy windows of 250~750 or 350~650 keV, respectively. Rat and mouse phantoms were used for measurement of SF (1 kBq) and NECR (0.1~200 MBq).

Results: Sensitivity and SF at each condition were summarized in table.


Figure 1

SF of I-124 was increased with activity amount: up to 53% (471.5 kBq/cc for rat). Sensitivity and peak NECR for I-124 was lower than those for F-18. Peak NECR of I-124 (80.7 kcps for rat) could be obtained at 2 times (for rat) or 4 times (for mouse) higher activity than for F-18 (94.64 kcps at 117.89 kBq/cc for rat).

Conclusions: This result reveals that to get better I-124 image requires higher injected activity. However, under the consideration of radiation absorbed dose and image quality, a refined protocol including scanner performance and acquisition duration, as well as object size, should be required for improved I-124 PET study.





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Right arrow Articles by Lim, S. M.
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Right arrow Articles by Kim, J. S.
Right arrow Articles by Lim, S. M.