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J Nucl Med. 2008; 49 (Supplement 1):401P
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Instrumentation & Data Analysis: Instrumentation

Instrumentation Posters

Evaluation of a pin-hole collimator used in conjunction with a novel solid-state gamma camera in small animals

Keisuke Uchida1, Hiroyuki Kurosawa1, Hiroyuki Kasahara1, Keita Utsunomiya2, Atsuro Suzuki3, Katsutoshi Tsuchiya3, Isao Takahashi3, Tsuneaki Kawaguchi3, Kensuke Amemiya3 and Takao Minamizawa1

1 Research Department, FUJIFILM RI Pharma Co., Ltd., Chiba, Japan; 2 Product & Market Planning Department, FUJIFILM RI Pharma Co., Ltd., Tokyo, Japan; 3 Central Research Laboratory, Hitachi Ltd., Ibaraki, Japan

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Objectives: A novel solid-state gamma camera (SSGC) has previously demonstrated a high spatial resolution and high energy resolution as compared to a conventional scintillation gamma camera (CSGC). The spatial resolution of SSGC equipped with a single pin-hole collimator was now evaluated in 99mTc-sestamibi and N-isopropyl-p-[123I] iodoamphetamine rodent imaging.

Methods: To evaluate the spatial resolution of a line source (inner diameter 0.5mm) planar and micro-Derenzo phantom SPECT images were acquired with a single pin-hole collimator (pin-hole diameter 0.38). For myocardial imaging, 99mTc-sestamibi 1590MBq was injected into a tail vein of the rat. Images were acquired 30min post injection. For brain imaging, N-isopropyl-p-[123I] iodoamphetamine 55.5MBq was injected into a tail vein of the mouse. Images were acquired 30min post injection. The FWHM of the line source was evaluated by the DRIP (FUJIFILM RI Pharma Co., Ltd., Japan) data analysis software.

Results: The mean FWHM of the line source were measured to be 0.49±0.3mm (mean±SD). All hot spots in the micro-Derenzo phantom (0.75, 1.0, 1.25, 1.5, 2.0, 2.5mm) were clearly identified. 99mTc-sestamibi SPECT SSGC images were clearly observed in the SHA, VLA, and HLA views. N-isopropyl-p-[123I] iodoamphetamine SPECT SSGC images clearly displayed the brain parenchyma.

Conclusions: The novel solid-state gamma camera equipped with a single pin-hole collimator provided higher spatial resolution and signal/noise ratio. The SSGC equipped with a single pin-hole collimator would be useful tool for evaluation in small animal imaging studies.





This Article
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Uchida, K.
Right arrow Articles by Minamizawa, T.
PubMed
Right arrow Articles by Uchida, K.
Right arrow Articles by Minamizawa, T.