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J Nucl Med. 2008; 49 (Supplement 1):39P
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General Clinical Specialties: Gastroenterology

Stomach, Esophagus and Pancreas

Various patterns of gastric emptying: A comparison of half time with four-hour retention

Kwang Chun1, Murthy Chamarthy1, Janine Feng1, Aaron Tokayer2, Daniel Behin2, Kalyan Mantripragada1, Khalid Saleemi1 and Leonard Freeman1

1 Nuclear Medicine; 2 Internal Medicine, MMC, Bronx, New York


Formula

156

Objectives: Gastric emptying study is the non invasive physiological study of the gastric emptying and motility functions. This study aims to compare various patterns of gastric emptying.

Methods: Patients with functional dyspepsia who underwent gastric emptying study in 2007 (n=162) were analyzed retrospectively. The gastric emptying half time and 4hr retentions were graded as normal (half time <90 minutes and 4hr retention <4% respectively) and abnormal groups. The data was analyzed for concordance and discordance of the result.

Results: The sensitivity, specificity, PPV, NPV of 4hr retention compared to half time were 64%, 92%, 90% and 69%, respectively. TP, FP, FN and TN for 4hr compared to half time were 34%, 4%, 19% and 43%. The half time and 4hr measurements showed a correlation of 0.78. The analysis of the half time and 4hr grades showed 22% discordance and a significant difference (p=0.01). The major discordance was for the studies with abnormal half time and normal 4hr retention. The mean 4hr retention was 8% for FP cases compared to 25% for TP cases (p=0.06).

Conclusions: The half-time missed 6/162 (4%) of the cases with abnormal 4hr retention. The 4hr retention was normal in 31 (19%) of the cases that had abnormal half time. In our series, though not significant because of less FP cases (n=6), the abnormal cases with both delayed half time and 4hr retention (TP) had more severe 4hr retention than the group with normal half time and delayed 4hr retention. With these varied patterns of gastric emptying, the 4hr values offer additional information to the conventional gastric emptying half time. Further clinical correlation will clarify the role of various patterns of discordant gastric emptying and available treatment options.





This Article
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Right arrow Articles by Freeman, L.