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Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
1 Nuclear Medicine, IRMET S.p.A. PET Center, Torino, Italy; 2 Onco-Hematology; 3 Operative Unit of Radiology, Regina Margherita Infant Hospital, Turin, Italy
1578
Objectives: Ewing’s sarcoma and osteosarcoma are typical children and adolescent malignant bone tumours. The lung is often the first site of metastatic spread. Early diagnosis of such lesions may increase the survival of patients after appropriate treatment. Aim of this prospective study was to evaluate (18F)-FDG-PET/CT for non invasive characterization of pulmonary nodules in these paediatric patients.
Methods: 11 patients with osteosarcoma and 12 with Ewing’s sarcoma were investigated. PET/CT results are correlated with histological findings.
Results: (18F)FDG-PET/CT correctly identified pulmonary metastases in 8 patients with osteosarcoma and in 5 with Ewing’s sarcoma. PET/CT scan was true negative in 3 patients of osteosarcoma group and true negative in 5 of Ewing’s sarcoma group. There were no false positive in both the two groups. No false negative were in Ewing’s sarcoma group. 2 patients of osteosarcoma group, (18F)FDG-PET/CT did not correctly identify pulmonary metastatic disease. In the first case the PET/CT finding was reported as inflammatory forms. In the second PET/CT scan was performed during chemiotherapy treatment. False negative result may be explained with the cellular stunning.
Conclusions: Our preliminary study suggest the feasibility of a correct characterization, by (18F)-FDG-PET/CT, of lung lesions, in paediatric patient with osteosarcoma or Ewing’s sarcoma. Therefore, prospective studies are needed to evaluate and establish the benefit of FDG-PET scan for the non invasive evaluation in this context.
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