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J Nucl Med. 2008; 49 (Supplement 1):36P
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Neurosciences: Neurology

Dementia II - Differential Diagnosis and Follow Up

Different cerebral metabolic features in dementia with Lewy bodies with/without visual hallucination

Hyun Soo Park1, Bom Sahn KIm1, Yu Kyeong Kim1, Yong Soon Yang1, Sang Soo Cho1, Sang Yun Kim1 and Sang Eun Kim1

1 Seoul National University College of Medicine, Seoul, South Korea

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Objectives: Reduction of glucose metabolism in the occipital cortex is well known in dementia with Lewy Bodies (DLB). The aim of this study was to evaluate the different nature of FDG PET in DLB patients who had visual hallucination or not.

Methods: Thirteen patients (72±9 yrs, m:f=6:7) with DLB participated. DLB patient were classified into two groups according to the presence of visual hallucination; seven DLB patients with visual hallucination,DLB-VH(+) and 6 patients without visual hallucination, DLB-VH(-). No differences between DLB-VH(+) and DLB-VH(-) was found in their cognitive function measured by mini mental status exam (MMSE) and clinical dementia rating (CDR) scale. Age and gender matched 30 healthy subjects (age; 71±5 yrs, m:f=13:17) served as controls for comparison purpose. Regional metabolic differences on FDG PET among the groups were tested using SPM.

Results: In DLB patients groups regardless of visual hallucination, significant regional hypometabolism were observed in the bilateral occipital cortices as well as bilateral parietotemporal and frontal association cortices when compared with healthy controls, as expected. In DLB-VH(+) compared to DLB-VH(-), regional hypometabolism over primary and secondary visual cortex (BA17, BA18) was more significant. Moreover, lower regional metabolism in the paracentral area (BA 6) and cerebellar vermis was also observed in DLB-VH(+) than DLB-VH(-).

Conclusions: Profound hypometabolism in the visual cortex may be a feature in DLB patients with visual hallucination. Also, relative hypometabolism in the paracentral area and cerebellum could be neurobiological characteristics related with abnormal cognitive and motor process response to hallucination.





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Park, H. S.
Right arrow Articles by Kim, S. E.
PubMed
Right arrow Articles by Park, H. S.
Right arrow Articles by Kim, S. E.