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J Nucl Med. 2008; 49 (Supplement 1):368P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Comparison of prognostic significance of FDG PET/CT in patients with poorly and well differentiated neuroendocrine carcinoma

Jaroslaw Cwikla1, Bogdan Malkowski2, Krzysztof Jeziorski3, Tomasz Pietrzyk2, Jaroslaw Szefer2, Anna Nasierowska-Guttmejer2, Jerzy Walecki1 and John Buscombe4

1 CMKP, Warsaw, Poland; 2 Oncology Center, Bydgoszcz, Poland; 3 CSK MSWiA, Warsaw, Poland; 4 RFH, London, United Kingdom

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Objectives: Prognostic significance of FDG PET in patients with poorly differentiated - PDNEC and well differentiated neuroendocrine carcinomas - WDNEC, base on progression free survival (PFS) and overall survival (OS).

Methods: This study comprised 31 pts, 17 with PDNEC, 14 with WDNEC. All had clinical, biochemical and imaging evaluation using anatomical and functional imaging of NET. In all of them FDG PET was performed as staging or restaging approach or evaluation of treatment (chemo) response. Active pathology was evaluated using clinical and radiological criteria. Kaplan-Meier survival curves were used to estimate PFS and OS, comparison between groups was performed using Cox-Mantel test.

Results: 12 PDNEC and 12 WDNEC patients presented progressive disease. There was significant SUV difference between PDNEC and WDNEC (8.4 vs. 4.9; p<0.05). Sensitivity of FDG PET/CT was 92%. Sensitivity WDNEC was 42%. OS and PFS in PDNEC with active disease were 21 and 7 months, in WDNEC, OS and PFS was 39 and 17 months, differences between OS in both groups (p=0.002). No significant difference between PFS. Only 2 of 12 patients with PDNEC and uptake of FDG were still alive during follow-up. In WDNEC only 2pts with high uptake of FDG died during follow-up.

Conclusions: Positive FDG PET/CT scan in patients with PDNEC, despite therapy, indicate active progressive disease with worse prognosis, compare to patients with negative FDG PET/CT. High sensitivity of FDG PET/CT could be routinely used to evaluation patients with PDNEC. Routine used of FDG PET in WDNEC due to low sensitivity is of limited value, high uptake is seen in selected cases with no additional prognostic value.





This Article
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Cwikla, J.
Right arrow Articles by Buscombe, J.
PubMed
Right arrow Articles by Cwikla, J.
Right arrow Articles by Buscombe, J.