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J Nucl Med. 2008; 49 (Supplement 1):366P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

[68Ga]DOTA-TATE- or [18F]DOPA-PET/CT: Which one is preferable for the diagnosis of neuroendocrine tumors (NET)?

Alexander Haug1, Christoph Auernhammer2, Peter Bartenstein1, Reinhold Tiling1, Bjoern Waengler1 and Gabriele Poepperl1

1 Department of Nuclear Medicine; 2 Department of Internal Medicine II, Ludwig-Maximilians-University, Munich, Germany

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Objectives: To compare the diagnostic value of [Ga-68]DOTA-TATE and [F-18]DOPA PET/CT in well differentiated metastatic NET.

Methods: PET/CT using both [Ga-68]DOTA-TATE and [F-18]DOPA was performed in 16 pts with histologically proven NET (9 gut/pancreas, 4 lung, 1 paranasal sinus, 2 unknown primary). PET examinations were analysed patient based (pathological uptake: yes/no) and based on tumor regions (TR: primary tumor, liver, lung, bone and lymph nodes) and compared among each other and with the results of contrast enhanced CT. Further on PET findings were correlated with serotonin levels in 14/16 pts.

Results: CT showed a primary tumor in 3/16 pts and metastases of one or several TR (in total 37 positive TR) in all pts, all presenting with pathological uptake in DOTA-TATE PET. DOPA PET was negative in 8/16 pts. In the remaining 8 pts 3/3 primaries and 17/20 positive TR demonstrated increased uptake. Overall, DOTA-TATE PET was superior to DOPA PET in 10 pts (8 pts with negative findings in DOPA PET and 2 pts with less positive TR) and delivered equal results in 6 pts. 7/14 pts showed elevated serotonin levels with 5/7 presenting pathological DOPA uptake. Positive DOPA uptake was also seen in 2/7 pts with normal serotonin.

Conclusions: In our patient population DOPA PET/CT was clearly inferior and added no diagnostic benefit compared to DOTA-TATE PET/CT. Positive DOPA uptake was seen in only half of the pts and seemed to correlate with elevated serotonin levels. In conclusion, DOTA-TATE PET should be considered as first line imaging modality for well differentiated NET while DOPA PET might only be useful in serotonin positive cases with negative DOTA-TATE PET.





This Article
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
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Google Scholar
Right arrow Articles by Haug, A.
Right arrow Articles by Poepperl, G.
PubMed
Right arrow Articles by Haug, A.
Right arrow Articles by Poepperl, G.