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Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
1 Johns Hopkins University, Baltimore, Maryland
1534
Objectives: Low FDG uptake has been reported in bronchioloalveolar carcinoma (BAC), potentially leading to false negative interpretations on PET alone. We correlated tumor density on CT with SUV max on FDG PET and the pathology results in patients with BAC or adenocarcinoma with BAC components (Adeno+BAC). Tumor size, FDG uptake and HUV were also determined.
Methods: This was a retrospective study on a consecutive series of 54 patients with 57 lesions (26 BAC, 31 Adeno+ BAC) who underwent FDG-PET/CT scan with the SUV and Hounsfield units (HU) reported. The correlation between SUV and HU was determined by using Pearson correlation coefficient test.
Results: A total of 26 lesions with BAC had a median SUV max of 1.48 (range, 0.63 to 4.54). 31 lesions diagnosed as Adeno+BAC had a median SUV max of 6.03 (range, 2.45 to 24) (p<0.0001). If the SUV was between 0 and 2.5 there was a 3.22% chance the nodule was Adeno+BAC, if between 2.5 and 4.0 it was 29 %, and if 4.1 or greater it was 67.8% in this series. The mean values of two groups are summarized in the table:
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A strong positive correlation between tumor size and HU was observed in Adeno+BAC group (P=0.0002).
Conclusions: PET/CT can help differentiate between BAC and adeno+BAC by using tumor size, CT density and metabolic activity. Pure BAC exhibits smaller size, lower FDG uptake and lower tumor density compared to Adeno+BAC. Many BAC have low SUV (<2.5) but their low HU on CT may aid in their proper recognition.
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