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J Nucl Med. 2008; 49 (Supplement 1):361P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Multi-FOV deep-inspiration breath-hold (DIBH) PET/CT: A possible role for whole-body imaging

Ukihide Tateishi1, Hiromitsu Daisaki2, Takeshi Murano2, Naoki Shimada2, Takashi Terauchi2, Yasunobu Yamada3, Satoshi Saito3, Nobutoku Motomura3 and Masahiro Kubota3

1 Diagnostic Radiology and Nuclear Medicine; 2 Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; 3 CT and Nuclear Medicine Development Department, Toshiba Medical Systems Corporation, Tokyo, Japan

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Objectives: DIBH PET/CT is a feasible modality to obtain better target localization and quantitation of the thorax. However, current performance of DIBH PET/CT is still limited by only one FOV (bed) acquisition and whole-body images can not be obtained. We proposed a newly developed Multi-FOV DIBH procedure to cover entire trunk affected by breathing.

Methods: PET/CT was performed in ten cancer patients (mean age; 62 years) under respiratory control with a commercially available device. CT was performed with the following scan parameters: axial 2.0-mm collimationx16 modes; 120kVp; 50mAs, 15.0 mm/sec table speed. DIBH scans were performed by six 10-s independent frames in five bed positions which covered patient trunk entirely 60 minutes after the iv administration of 300-370 MBq of 18FDG. Subsequently, conventional emission scans from the head to the mid-thigh were performed with 1 min acquisition time in seven bed positions. Images were reconstructed with attenuation-weighted OSEM with 4 iterations and 14 subsets.

Results: PET images of Multi-FOV DIBH showed more clear delineation of diaphragm, vertebra, thoracic wall, hepatic edges, and pulmonary nodules and vessels. Coronal PET/CT images displayed little banding artifacts whose bad displacements were linearly related to respiratory motion. The tumor-to-background ratio of the tumors in multi-FOV DIBH images improved significantly compared with those of control PET/CT.

Conclusions: Multi-FOV DIBH PET/CT allows for better visualization of target lesions in the chest and upper abdomen.





This Article
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Right arrow Articles by Tateishi, U.
Right arrow Articles by Kubota, M.