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J Nucl Med. 2008; 49 (Supplement 1):360P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

I-124 PET/CT vs. I-131 WBS in patients with recurrent/metastatic thyroid carcinomas

Hani Abdel-Nabi1, Scott Wisniewski1, Deborah Erb1, Munawwar Sajjad1 and Erol Bars1

1 Nuclear Medicine, University at Buffalo, Buffalo, New York

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Objectives: To compare the accuracy of I-124 PET/CT to I-131 whole body scintigraphy (WBS) in the detection of recurrence and metastases in pts with differentiated thyroid carcinomas who have been previously treated with Iodine-131.

Methods: Eight pts (4 females, 4 males) with differentiated thyroid carcinomas (6 papillary, 1 follicular, 1 Hurthle cell) were enrolled in this prospective study. Patient ages ranged from 26-72 (mean 42.5 years). Local recurrences were suspected by ultrasound in the thyroid bed in 3 pts, local lymph nodes metastases in 2 pts by physical examination, and one pt based on an abnormal FDG PET/CT. Two pts presented with abnormally elevated thyroglobulin levels. Imaging protocol: Six pts received 2.2 mCi of I-131 orally while off thyroid hormone and two pts received 4.0 mCi Na-I-131 following Thyrogen stimulations. Patients were imaged 48 hours later on a dual-head camera fitted with high energy collimators. Immediately following the completion of the I-131 WBS, the pts received ~ 1.41 mCi of Iodine-124 orally. PET/CT were performed 4, 24, and 48 hours laters on a CTI Reveal XVI HREZ scanner.

Results: Iodine-124 PET/CT scans were positive in 3 pts with local recurrence in the thyroid bed (1), paratracheal lymph node (1), and thyroid bed and lymph node mets in one. On the contrary, none of the I-131 WBS were positive. Recurrence/mets were confirmed biochemically and FDG PET/CT scanning. All lesions were seen as early as 4 hours following Iodine-124 scanning.

Conclusions: In pts with recurrent/metastatic thyroid carcinoma and negative I-131 whole body scans, Iodine-124 PET/CT scanning might allow the exact assessment of recurrent and metastatic disease. Lesions could be visualized as early as 4 hours post I-124, although delayed imaging provided a better tumor to background ratio.





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Right arrow Articles by Abdel-Nabi, H.
Right arrow Articles by Bars, E.
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Right arrow Articles by Abdel-Nabi, H.
Right arrow Articles by Bars, E.