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J Nucl Med. 2008; 49 (Supplement 1):358P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Preoperative PET SUV of neck nodes predicts neck control and survivals in oral cavity squamous cell carcinoma patients

Liao Chun-Ta1, Joseph Tung-Chieh Chang1 and Yen Tzu-Chen1

1 Head and Neck Oncology Group, Chang Gung Memorial Hospital & Chang Gung University, Taoyuan, Taiwan

1515

Objectives: This aim was to study whether SUV of neck nodes would predict outcome in Oral Cavity Squamous Cell Carcinoma (OSCC) patients.

Methods: Patients with documented OSCC were enrolled. All underwent a PET scan within two weeks before treatment. Optimal cutoff value of SUV was chosen based on 5-year disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS). Independent prognosticators were identified by Cox regression analysis.

Results: 102 patients were enrolled. The optimal cutoff values for SUV were 5.7 and 4.1, respectively. In patients with a SUV cutoff of 5.7, multivariate analyses (MVA) identified the following independent predictors of poor outcome: SUV≥5.7, pN2, and poor differentiation for the 5-year neck control (NC); SUV≥5.7 for the 5-year distant metastasis (DM) and for 5-year DFS; extracapsular spread (ECS) and age of onset ≤40 years for the 5-year DSS, and ECS for the 5-year OS. In patients with a SUV cutoff of 4.1, MVA identified the following prognosticators: pN2 and poor differentiation for the 5-year NC; SUV≥4.1 for the 5-year DM and DFS; SUV≥4.1 and ECS for the 5-year DSS, and SUV≥4.1 and pathological margin ≤4mm for the 5-year OS. A scoring system using SUV≥5.7, pN2, and poor differentiation as covariates defined three prognostic groups for 5-year NC: score≤1 (HR=1); score 2 (P=0.008), and score 3 (P<0.001). A scoring system using SUV≥4.1 and ECS as covariates defined two prognostic groups for 5-yr DDS: score=0 (HR=1) and score≥1 (P=0.002).

Conclusions: SUV of 5.7 and 4.1 and neck nodes were independent prognosticators for NC and survivals.

Research Support: CMRPG36007 National Science Council of Taiwan (NSC-95-2314-B-182A-136-MY3)





This Article
Services
Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Chun-Ta, L.
Right arrow Articles by Tzu-Chen, Y.
PubMed
Right arrow Articles by Chun-Ta, L.
Right arrow Articles by Tzu-Chen, Y.