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J Nucl Med. 2008; 49 (Supplement 1):357P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

2-(18F)-Fluoromethyl-L-phenylalanine PET in progressive glioma

Hendrik Everaert1, Cristo Chaskis2, Vicky Caveliers1, Tony Lahoutte1, John Mertens3, Ken Kersemans3, Christian Vanhove1, Matthias Bauwens3, Axel Bossuyt1 and Bart Neyns4

1 Nuclear Medicine; 2 Neurosurgery; 3 Radiopharmaceutical Chemistry and Sciences; 4 Medical Oncology, UZ Brussel, Brussels, Belgium

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Objectives: To evaluate 2-18F-Fluoromethyl-L-Phenylalanine (FMP), a new PET tracer, in recurrent glioma pts. Several amino acids accumulate intensively in malignant cells, due to L-type amino acid transport system overexpression. Uptake of these compounds in normal brain is low which makes them valid alternatives for FDG for the imaging of primary brain tumors.

Methods: Ten glioma pts (5M/5F, age 47 ± 12 yr, initial WHO: grade II: 4, grade III: 1, grade IV: 4), classified as progressive based on clinical signs and serial MR, were included. Dynamic PET data were acquired for 40 min. starting immediately after administration of 156 ± 57 MBq FMP. Dynamic and summed data were reconstructed iteratively. Volumes of interest over tumor and normal brain were manually placed. Maximal SUV values within the tumor were assessed, for the non-target region the average SUV value was measured. Tumor-to-background (T/B) ratio’s were calculated.

Results: FMP uptake in non-affected brain tissue was low: SUV 1.56 ± 0.57. At sites of known and suspected progression as identified by MR, increased FMP uptake was seen for all pts, with SUVmax ranging from 2.42 to 7.56 (mean ± SD: 4.66 ± 1.51). The time to reach maximum SUV within the tumor ranged from 3 to 16 min. (mean 9 min.) and was immediately followed by a washout phase. T/B ratio’s ranged from 1.83 to 4.33 (mean ± SD: 2.88 ± 0.81).

Conclusions: In this group of progressive glioma pts intense FMP accumulation was observed in all known tumor sites. Uptake in the normal brain was low rendering high T/B ratio’s. Maximum FMP accumulation within the tumor is rapidly reached after administration allowing early imaging.





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Google Scholar
Right arrow Articles by Everaert, H.
Right arrow Articles by Neyns, B.
PubMed
Right arrow Articles by Everaert, H.
Right arrow Articles by Neyns, B.