SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):355P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Wong, C.-y.
Right arrow Articles by Huang, W.-s.
PubMed
Right arrow Articles by Wong, C.-y.
Right arrow Articles by Huang, W.-s.

Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Time sensitivity: Another metabolic phenotype of tumor by FDG PET

Ching-yee Wong1, Daniel Noujam1, Hung-sen Fu2, Cheng-yi Cheng2, Chih-yung Chang2, Joseph Thie3 and Wen-sheng Huang2

1 Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan; 2 Nuclear Medicine, Tri-service General Hospital, Taipei, Taiwan; 3 University of Tennessee, Knoxville, Tennessee

1499

Objectives: To investigate the newly defined time sensitivity (S) of tumor by serial FDG PET.

Methods: Dual time (t) protocol (P) FDG PET scans from 40 pts with pathologically proven head and neck (H&N) tumors without brain metastasis were analyzed. P.I (1.5 & 2-hr): 26 pts (M:F=20:6, age=61±17) with early (E) and delayed (D) PET obtained at 106±15 and 135±16 min after injection of 16.3±1.9 mCi FDG. P.II (1 & 2-hr): 14 pts (M:F=12:2, age=55±12) with E and D PET performed at 54±13 and 151±28 min after injection of 9.6±1.7 mCi FDG. The serum glucose (Glu) was recorded before each scan and the maximum SUV were measured in the primary tumor (CA1) and the cerebellum (CBL). S =d{ln(SUV)}/d{ln(t)} was obtained by linear regression of ln (SUV) vs ln (t). Paired t-tests with p<0.05 was considered significant.

Results: D SUV were significantly higher than E SUV in CA1 for both P.I (18.3±6.9 vs 14.3±5.8, p<0.0005) and P.II (11.5±7.9 vs 9.7±6.9, p=0.013). The S values for CA1 in P.I and P.II were 1.12 and 0.15 respectively. Glu was not significantly different in both P.I and P.II (103±25 vs 93±14, p=ns). The D SUV were also higher than E SUV in CBL for both P.I (12.1±2.2 vs 11.2±2.5, p<0.0005) and P.II (7.6±1.6 vs 7.0±1.6, p=0.008). The S values for CBL in P.I and P.II were 0.39 and 0.017 respectively, which were over 2-fold smaller than that of CA1, suggesting phenotypic differences between CA1 and CBL.

Conclusions: There exists another metabolic phenotype of CA1 besides SUV measured by the newly defined S using serial FDG PET. It offers another useful Dx tool in optimizing choices of dual time protocols and in reducing SUV variations due to time differences.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Wong, C.-y.
Right arrow Articles by Huang, W.-s.
PubMed
Right arrow Articles by Wong, C.-y.
Right arrow Articles by Huang, W.-s.