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Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
1 Gynecology Oncology Group, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan
1495
Objectives: Both diffusion-weighted MRI (DWI) and FDG PET/CT has been shown to be feasible clinical techniques for cancer studies. Currently, apparent diffusion coefficient (ADC) measured by DWI and SUV from FDG PET/CT have been applied in similar clinical applications in oncology. The aim of this study was to assess the correlation between ADC and SUV in primary cervical cancer.
Methods: Patients with documented primary cervical cancer were recruited. To avoid partial volume effect, patients with tumor diameter<2cm were excluded. All participants underwent abdominopelvic DWI at 3T and FDG PET/CT scans within two weeks after tissue proven. For the primary tumor, ADC was measured as minimum ADC representing highest tumor cellularity, mean ADC, and total ADC within the tumor volume by DWI. Maximum SUV, mean SUV, and total lesion glycolysis (TLG) were measured by FDG PET/CT.
Results: Totally, 29 patients were included. There was no significant correlation either between minimum ADC and maximum SUV or between mean ADC and mean SUV. For the whole tumor volume, total ADC was significantly correlated to TLG (r=0.925, P <0.001).
Conclusions: Due to insignificant correlation between ADC and SUV, whether ADC can be recognized as a similar role of SUV in primary cervical cancer is still doubtful. The significant correlation of total ADC with TLG implies the complementary role of each other in assessing tumor response in the future.
Research Support: Taiwan National Science Council (NSC 95-2314-B-182A-136-MY3) and Chang Gung Memorial Hospital (CMRPG 340091) research grants.
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