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Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
1 Clinical Radiology; 2 Anatomic Pathology; 3 Health Science, Kyushu University, Fukuoka, Japan
1486
Objectives: We analyzed the ability of FDG-PET for detecting lymph node metastasis in the patients with esophageal cancer. We also compared the FDG-PET results with the pathological features of metastasized lymph nodes.
Methods: Twenty-eight patients (25 males and 3 females, 44 to 78 years old, mean: 60.9 years old, all squamous cell esophageal cancers) who underwent surgery including lymph node resection were selected for this study. Using pathological results as a gold-standard, we examined sensitivity, specificity and accuracy of FDG-PET for detecting lymph node metastasis. We measured the size of metastasized lymph nodes using Image-J and examined the ratio of cancer cell area to whole lymph node area with visual estimation. As an index for the number of metastasized cancer cells, we multiplied whole lymph node area with the ratio of cancer cell area. Following this, we evaluated the correlation between FDG-PET results together with nodal size, ratio value and index of cancer cell number.
Results: Sensitivity, specificity, and accuracy of FDG-PET were 52.9%, 90.9% and 67.9%, respectively. Twenty-eight lymph nodes from 13 patients showed metastasis, in which 16 were FDG-PET (+) and the remainder FDG-PET (-). Lymph node size and the index for the number of cancer cells had significant correlation with FDG accumulation, though the ratio of cancer cell area did not (p-value of exact test were <0.0001, <0.0001 and 0.068 respectively).
Conclusions: Together with pathological findings, we ensured that the nodal size and the number of cancer cells within the lymph nodes were important factors for detection using FDG-PET.
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