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J Nucl Med. 2008; 49 (Supplement 1):350P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Can PET/CT predict complete response of esophageal cancer to chemo radiation therapy?

Mark Tann1, Leah Sieck1, Chistopher Fisher1 and James Fletcher1

1 Radiology, Indiana University School of Medicine, Indianapolis, Indiana

1479

Objectives: Chemo radiation is a common neo-adjuvant therapy used to treat esophageal cancers. In approximately 20% of the cases it can cause a complete remission, based on post-operative data. Therefore, potentially 20% of the esophageal resections were not needed. FDG PET/CT is commonly used for the initial staging and evaluation of treatment response. We wanted to evaluate if PET/CT in the post chemo radiation setting is accurate for the evaluation of complete response.

Methods: 21 patients with a history of esophageal cancer treated by chemo radiation, selected for surgical resection were included in the study. A comparison was made between the post-surgical esophageal pathology findings and the presurgical PET/CT report and esophageal SUV Max. All PET/CT studies were performed at least 6 weeks post radiation.

Results: Neither by visual analysis or by SUV analysis could complete response be differentiated from residual tumor. The range of SUV max from the regions of treated esophageal cancer was, average 4.9 SD 2.1 (range 1.7-7.2) in cases of complete response and average SUV 5.4 SD 2.2(Range 2 - 8.9) in those with residual tumor.

Conclusions: PET/CT can not differentiate between complete response and residual tumor in post chemo radiation treated esophageal cancer





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