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J Nucl Med. 2008; 49 (Supplement 1):349P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

The incremental value of high dose contrast enhanced CT with dual phase helical CT (DPCT) to FDG PET/CT recurrent pancreatic carcinoma (PC)

Eduardo Moroni1, Christopher Chin1, William Simpson1, Jong Kim1, Sherif Heiba1, Josef Machac1 and Lale Kostakoglu1

1 Radiology, Mount Sinai Medical Ctr, New York, New York

1478

Objectives: Our aim was to investigate the accuracy of FDG PET/CT in comparison and in addition to HDCT done with DPCT in the evaluation of recurrent PC.

Methods: A total of 82 lesions were evaluated on 29 PET/CT and HDCT/DPCT at restaging of PC pts. The accuracy of PET/CT and HDCT/DPCT was compared and incremental value of both modalities was assessed. The results were confirmed by pathology (n=15) or follow-up (median 6 mo).

Results: Overall, PET/CT had a higher accuracy than HDCT. There were 10 equivocal HDCT results(no equivocals on PET/CT). Combined PET/CT and HDCT yielded a higher specificity (SP) and positive predictive value (PPV) than each method alone regardless of equivocals considered positive or negative.


Figure 1
Analyses for PET/CT, HDCT, Combined PET/HDCT

The majority of recurrences were in the liver and pancreatic bed. For liver lesions, the SP, PPV and accuracy of combined PET/CT and HDCT was superior to each method alone. For pancreatic bed lesions, all statistical measures for combined PET/CT and HDCT were as high as for PET/CT, and superior to HDCT.

Conclusions: The accuracy of combined PET/CT and HDCT is superior to either method alone in detection of recurrent PC. Although our results should be reproduced in a larger sample size, combined PET/HDCT approach is promising for increasing accuracy in detection of recurrent PC.





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