J Nucl Med. 2008; 49 (Supplement 1):347P
Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
Efficacy of PET/CT for colorectal cancer screening
S. Yasuda1,
K. Kobayashi2,
T. Katoh2,
M. Itoh2,
M. Ohta2,
T. Kojima2,
N. Ushimi2,
K. Akiyama2,
H. Nakajoh2 and
H. Makuuchi1
1 Tokai University School of Medicine, Isehara, Japan;
2 Yotsuya Medical Cube, Tokyo, Japan
1466
Objectives: PET has potential for screening colorectal carcinoma (CRC). However, physiologic bowel uptake (PBU) may hamper detection of CRC. We evaluated the efficacy of PET/CT for CRC screening.
Methods: From May 2005 to June 2007, 1968 asymptomatic individuals (1188 men, 780 women, 54.6±11.8 yo) underwent 2351 PET/CT studies. PET/CT images were evaluated visually, and findings were classified prospectively as 1) positive: localized FDG uptake and presence of CRC was suspected; 2) equivocal: localized FDG uptake but distinction between CRC and PBU was difficult; 3) negative: no apparent FDG uptake; or 4) not evaluable (NE): evaluation was impossible because of PBU. PET findings were compared to subsequent colonoscopic findings.
Results: The incidence of positive or equivocal findings was 2.8% (Table). 37/66 cases (56%) underwent colonoscopy, and 14 lesions were detected in 13 subjects: 7 CRCs, 6 adenomas, and 1 ulcerative lesion. PPV of a PET-positive result was 40%. The CRC detection rate was 0.3% (7/2351 studies) and exceeded the reported detection rate of 0.15% by fecal occult blood test. The carcinoma and adenoma detection rates were 0.6% (12/1968 individuals). The incidence of incomplete screening resulting from PBU was 1.7%.
Conclusions: PET/CT is potentially efficacious for CRC screening. Carcinoma or adenoma can be incidentally detected during PET/CT study at a rate of not less than 0.3-0.6%.
