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Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
1 Research Institute, Shiga Medical Center, Moriyama-City, Japan; 2 Surgery; 3 Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan
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Objectives: Intrahepatic cholangiocarcinoma (ICC) is known for its poor prognosis, and lymph node metastasis is an important prognostic factor. We have investigated the diagnostic values of FDG-PET as a marker for P-glycoprotein (P-gp) expression and recurrence in hepatocellualr carcinoma. In this paper, we investigated those of FDG-PET in ICC.
Methods: The subjects were 30 patients with ICC who underwent FDG-PET and underwent surgery. Detectability of lymph node metastasis using FDG-PET was compared with that using computed tomography (CT) or magnetic resonance imaging (MRI). In patients who underwent resection, expression of P-gp was examined immunohistochemically, and the relationship between P-gp expression and the standardized uptake value (SUV) in FDG-PET was investigated. Survival rates were analyzed using clinical and pathological factors.
Results: The diagnostic accuracies of FDG-PET, CT and MRI for detection of lymph node metastasis were 85.7%, 67.9% and 57.1%, the sensitivities were 42.9%, 42.9% and 42.9%, and the specificities were 100%, 76.2% and 64.3%, respectively. A negative correlation was found between SUV and P-gp expression (p=0.002, r=-0.62). The disease-free survival rates in the high SUV group (
8.5) were significantly lower than in the low SUV group (< 8.5) (p = 0.04), and a high SUV was an independent predictor of postoperative recurrence in multivariate analysis (risk ratio, 1.3; p = 0.03).
Conclusions: Our data suggests that FDG-PET has a diagnostic usefulness in the prediction of lymph node metastasis, P-gp expression and recurrence in ICC.
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