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Oncology-Clinical Diagnosis: Solid TumorsClinical Diagnosis-Solid Tumors Posters |
1 Nuclear Medicine; 2 Surgery, Yeungnam University Hospital, Daegu, South Korea
1457
Objectives: Although frequently used for colorectal cancer surveillance, the sensitivity of carcinoembryonic antigen (CEA) to detect recurrence is not optimal. The purpose of this retrospective study is to evaluate the sensitivity of F-18 FDG PET/CT for detection of recurrent colorectal cancer after curative surgical resection, compared with serum CEA level.
Methods: F-18 FDG PET/CT was performed on 715 patients with curative treatment of colorectal cancer from Aug. 2004 to Nov. 2007. They were checked serum CEA level within 3 months before or after F-18 FDG PET/CT. Final diagnosis of recurrence was proved histologically or radiologically in 79 patients ( male 52, mean age 60.7 ± 11.8 years old).
Results: Seventy- eight of the 79 patients showed suspected lesions on F-18 FDG PET/CT. A patient( CEA =77.4 ng/ml) who didn’t show abnormal lesion in F-18 FDG PET/CT proved to be peritoneal carcinomatosis after 5 months. Five of 78 patients showed only lung nodules on CT without significant FDG uptake. Forty of 79 patients(51%) showed increased serum CEA ( > 10 ng/ml) and 12 patients(31%) with lesser than 10 ng/ml serum CEA level showed an increasing pattern in serial examination.
Conclusions: F-18 FDG PET/CT has high sensitivity in the detection of recurrent colorectal cancer patients who received curative surgical resection even in patients with normal CEA level.
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