SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Nucl Med. 2008; 49 (Supplement 1):344P
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Ahmadzadehfar, H.
Right arrow Articles by Palmedo, H.
PubMed
Right arrow Articles by Ahmadzadehfar, H.
Right arrow Articles by Palmedo, H.

Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Significance of Bremsstrahlung scans in patients treated by selective internal radiation therapy (SIRT)

Hojjat Ahmadzadehfar1, Amir Sabet1, Holger Brockmann1, Elham Habibi1, Samer Ezziddin1, Hans-Jürgen Biersack1 and Holger Palmedo1

1 University Hospital, Bonn, Germany

1456

Objectives: Due to the fact that Y-90, which is used in SIRT,is a pure beta emitter,the only way to visualize the accumulation of microspheres in the liver is to obtain low-resolution Bremsstrahlung scans.The aim of this study is to evaluate the role of post therapeutic Bremsstrahlung scans in confirming the distribution of microspheres in liver.

Methods: We performed 42 intra arterial therapies in 37 patients with liver tumor or metastases from different carcinomas. Patients were treated with SIRT after a previous Tc-MAA scan to determine the degree of shunting from the liver to the lung or gastrointestinal tract.Patients received one intra arterial injection via angiography catheter (mean 1.86 GBq) of Y-90 labeled microspheres (SIRTSpheres, Comp. SIRTEX). Whole body Bremsstrahlung scans were performed in all patients 24 h after therapy. These scans were compared to MAA-scans to confirm the distribution of the therapeutic microspheres.

Results: The distribution pattern of Tc-99m-MAA and Bremsstrahlung scans was identical in all patients.In 17 scans(41%) metastases/tumors could be identified and differentiated from the liver parenchyma,despite low resolution of Bremsstrahlung scan. In just only one patient, an abnormal accumulation in the stomach wall was detected in SIRT which was not previously detectable in the MAA-Scan, in spite of the identical catheter position in both cases. This unwanted gastric accumulation, confirmed later by gastrointestinal endoscopy, could explain the patient’s clinical symptoms (nausea, heavy vomiting).

Conclusions: The Bremsstrahlung scan can be used as a reliable method to confirm the distribution of Y-90 microspheres.A discrepancy between MAA and Bremsstrahlung scan,even if rarely,necessitates implementation of the Bremsstrahlung scan due to its clinical relevance.





Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Ahmadzadehfar, H.
Right arrow Articles by Palmedo, H.
PubMed
Right arrow Articles by Ahmadzadehfar, H.
Right arrow Articles by Palmedo, H.