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J Nucl Med. 2008; 49 (Supplement 1):343P
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Oncology-Clinical Diagnosis: Solid Tumors

Clinical Diagnosis-Solid Tumors Posters

Breast cancer pathology: Correlation with PET/CT derived standardized uptake values

Josephine Rini1, Keyur Patel2, Asad Nasir1, Eran Ben-Levi3, Jason Naidich3, Christopher Palestro1 and Nichols Kenneth1

1 Division of Nuclear Medicine; 2 Dept Pathology; 3 Dept Radiology, North Shore-Long Island Jewish Health System, New Hyde Park, New York

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Objectives: To investigate relationships between breast cancer (BCa) pathology & maximum standardized uptake values (SUV) as measured on PET/CT.

Methods: This retrospective investigation included 25 female patients (age 61±14 yrs) with 26 new or locally recurrent BCa who underwent preoperative PET/CT between 07/2006-12/2007, with pathology (mastectomy (n=15) & lumpectomy (n=11)) demonstrating tumors >1 cm in maximum dimension. Official reports were reviewed to determine pathology & BCa SUV. Rank correlation tested relationships between SUV & BCa histology, tumor grade, Scarff-Bloom-Richardson (SBR) score (a pathologic BCa grading system that correlates with disease-free survival), and estrogen receptor (ER) & progesterone receptor (PR) expression.

Results: Final histologic diagnoses were: Invasive ductal carcinoma (Ca) (n=22): grade 1 (n=2); grade 2 (n=8); grade 3 (n=12); Invasive lobular Ca (n=3): grade 2 (n=3); & papillary Ca (n=1): grade & SBR score were not reported for this low grade tumor. Maximum tumor dimension was 2.7+1.8 cm (range 1.0-8.5 cm). Rank correlation for SUV & BCa histology was marginally significant (p=0.049). There was a significant association between SUV & tumor grade (p=0.016) and SUV & SBR score (p=0.003). SUV was not related to ER expression (p=0.134) & was weakly associated with PR expression (p=0.032).

Conclusions: There was a significant association between SUV & tumor grade and SUV & SBR score. Since the SBR score correlates with disease-free survival, these findings suggest that SUV may be a useful prognosticator of disease-free survival in patients with BCa.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
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Right arrow Articles by Rini, J.
Right arrow Articles by Kenneth, N.
PubMed
Right arrow Articles by Rini, J.
Right arrow Articles by Kenneth, N.