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J Nucl Med. 2008; 49 (Supplement 1):340P
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Oncology-Clinical Diagnosis: Hematologic Tumors

Hematology Malignancy

An administrative structure for integration of multimodality image implementation and tumor-metric analysis for early assessment of therapeutic response in cancer by Image Response Assessment Teams (IRAT)

James Mountz1, Ashok Muthukrishnan1, Badreddine Bencherif1, Barry McCook1, Judith Joyce1, Kenneth Foon2, Charles Laymon1, Darlene Frasher2, Erin Deeb2 and Ronald Herberman2

1 Radiology, Division of Nuclear Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; 2 Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

1437

Objectives: The proper selection of multi-modality imaging to assess efficacy of novel anti-cancer therapeutic agents requires careful consideration early in cancer therapy trial design. This study measures the effect of the University of Pittsburgh Cancer Institute's (UPCI) IRAT program on inclusion of CT and FDG PET in therapy trials.

Methods: Cancer therapy trials were assessed before and after implementation of IRAT for utilization of CT and FDG PET. Image modality for tumor metric measurement was obtained for UPCI cancer therapy trials 1 year prior to IRAT compared to 1 year after IRAT implementation.

Results: Forty protocols were assessed before and after IRAT implementation


Figure 1

. In addition to increasing FDG PET inclusion in trial design, IRAT facilitated PACS storage and server development for triage and analysis of images and provided a conduit for efficient image data exchange.

Conclusions: IRAT increased use of FDG PET and streamlined image management in cancer therapy trials.

Research Support: 5P30CA047904 NIH





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Right arrow Articles by Mountz, J.
Right arrow Articles by Herberman, R.