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J Nucl Med. 2008; 49 (Supplement 1):336P
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Oncology-Clinical Diagnosis: Hematologic Tumors

Hematology Malignancy

Varying degrees of FDG accumulation in malignant lymphoma based on WHO histological classification

Ryogo Minamimoto1, Keisuke Yoshida1, Akiko Suzuki1, Kazuya Shizukuishi1, Nobukazu Takahashi1, Jin Lee1 and Tomio Inoue1

1 Department of Radiology, Yokohama City University, Yokohama, Japan

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Objectives: The aim of this study is to clarify the varying degrees of FDG accumulation in malignant lymphoma based on WHO histological classification, and to suggest the histological subtypes suitable for evaluation with PET/CT rather than PET.

Methods: During 2001 to 2007, FDG-PET or PET-CT was performed 762 examinations in 249 patients with histologically-confirmed diagnosis of malignant lymphoma based on WHO histological classification. Among those, 111 examinations were performed in pretreatment state ( Diffuse large B-cell lymphoma [DLBCL]: 46, Marginal zone B-cell lymphoma [MALT]: 20, T-cell and NK-cell neoplasms: 16, Follicular lymphoma [FL]: 11, Hodgkin lymphoma [HL]: 10, Mantle cell lymphoma [MCL]: 3, Lymphoblastic lymphoma: 3, Burkitt lymphoma: 2 ). The maximum SUVs were analyzed according to histological classification.

Results: The averages of maximum SUVs were DLBCL of 12.0±6.8, MALT of 4.7±2.3, T-cell and NK-cell neoplasms of 7.9±4.9, FL of 5.1±2.0, HL of 7.5±2.2. There was statistically significant difference in maximum SUVs between DLBCL and MALT, DLBCL and FL. FDG-PET is sufficient methodology for evaluating DLBCL since FDG accumulation in DLBCL is high enough. It appears that evaluation with PET/CT, rather than PET, was suitable for histological subtypes with low FDG accumulation such as MALT, for extranodal lesion.

Conclusions: Degrees of FDG accumulation in malignant lymphoma varied with histological subtypes. It should be taken into consideration for selecting evaluative method for malignant lymphoma.





This Article
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Minamimoto, R.
Right arrow Articles by Inoue, T.
PubMed
Right arrow Articles by Minamimoto, R.
Right arrow Articles by Inoue, T.