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J Nucl Med. 2008; 49 (Supplement 1):331P
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Oncology-Basic Science: Therapy, Metrics & Intervention

Therapy, Metrics & Intervention Posters

Effect of kinetic parameters in assessing early treatment response of VX2 rabbit tumor model for dynamic FDG study

Shaoli Song1, Lingfeng Wen2, Gang Huang1, Chuang Deng3, Jianjun Liu1, Ching-yee Oliver Wong4 and Dagan Feng2

1 Renji Hospital, Shanghai JiaoTong Univ, China; 2 Sydney Univ, Sydney, New South Wales, Australia; 3 Hong Kong Sci Tech Univ, Hong Kong, China; 4 William Beaumont Hospital, Michigan State Univ, Michigan

1401

Objectives: This study systematically investigated the effect of quantitative parameters in the early assessment of treatment response using VX2 rabbit tumor model and FDG PET/CT imaging for cisplatin (CDDP) administration.

Methods: 32 rabbits were studied with 2 VX2 squamous cell tumors implanted in each rabbit. Dynamic FDG PET/CT studies were performed before CDDP administration and at the various time points of post-treatment 40 min (D0), 1 day (D1) and 7 day (D7). The nonlinear regression (NLR) method estimated the parameters of K1, K2, K3, K4, deriving MRglc and influx rate of KiNLR. The influx rate (KiPAK) was also derived by the Patlak method as well as the mean of SUV (SUVmean) for the comparison. The tumors were classified into an insensitive group if the tumor volume was doubled on the 7th day, vice versa.

Results: The changes of the parameters were derived by comparing the values of pre- and post-treatment. The mean and standard deviation (SD) of the parameters were listed in the table with all the time points and tumor models considered. {Delta}SUVmean was correlated with the changes of K1, MRGlc, KiNLR and KiPAK for D0. K1 shows more sensitivity than other parameters respectively for the results of D0, D1 and D7 in the two groups.

Conclusions: Quantitative kinetic analysis shows potential in accurately assessing early treatment response. K1 is more sensitive than other parameters and hence may aid early discrimination of the sensitive tumors from the insensitive tumors.


Figure 1
The changes of different parameters





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