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Oncology-Basic Science: Therapy, Metrics & InterventionTherapy, Metrics & Intervention Posters |
1 Nuclear Medicine; 2 Surgery, MGH & Shriners Hospital for Children, Boston, Massachusetts
1396
Objectives: A terrorist attack could involve the release of radiation followed by fire. Thus, victims could be exposed to elevated levels of radiation plus severe burn injury. This study investigated the effects of radiation±burn injury on FDG uptake.
Methods: 4 groups (GPs) of 6 mice (~30 g) were studied. GP-1(R): Irradiation with a 137Cs source (950 RADS, 4.75 min). GP-2(B): 25% (total body surface area) full thickness burn. GP-3(R+B): Radiation followed 10 min. later by burn. GP-4(S): Sham treated controls. Burned mice were resuscitated with saline (2 mL, IP). After fasting for 18h after treatment, the mice were injected with 5 µCi of FDG, sacrificed 1 h later and biodistribution was measured. Results were expressed as %ID/g (mean±sen).
Results: R ± B produced major changes in FDG uptake by many tissues
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. Heart: R or B produced small increases (p<0.05), whereas R+B produced a massive increase (p<0.0001). Lung & liver: R or B produced small decreases, whereas R+B produced a small increase (p<0.05). Testes: All 3 treatments produced moderate decreses in uptake (p<0.01). Brain: All 3 treatments produced marked decreses in uptake (p<0.001). Brown fat (BAT): All 3 treatments especially the combination produced marked increase in uptake (p<0.001 to p<0.0001).
Conclusions: The combination of radiation and burn injury alters FDG uptake in a number of tissues. This model may be useful in developing treatments for victims of injuries suffered by terrorism.
Research Support: NIH & Shriners Hospitals for Children
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