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J Nucl Med. 2008; 49 (Supplement 1):325P
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Oncology-Basic Science: Therapy, Metrics & Intervention

Therapy, Metrics & Intervention Posters

Evaluation of metastatic bone lesions using 11C-methionine PET imaging in patients with lung cancer

Sherif Abd-Elrazek1, Kyosan Yoshikawa1, Mitsuhiko Hasebe1, Seiya Ohashi1, Hiroyuki Ishikawa1, Kenji Sagou1, Katsumi Tamura1, Susumu Kandatsu1, Masayuki Baba1 and Tsuneo Saga1

1 Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan

1379

Objectives: The aim of our study was to evaluate the diagnostic accuracy of the amino acid radiotracer 11C-methioine (MET) in the detection of metastatic bone lesions in lung cancer patients.

Methods: MET PET studies done for forty three lung cancer patients were evaluated retrospectively for the presence of metastatic bone lesions. Evaluation of bone areas with suspected abnormal MET uptake was done according to 3-point-scale as high, equivocal or low possibility metastatic. Concurrent bone scan (BS), within one month interval, was available for comparison in twenty five cases. The presence of bone metastasis was confirmed by late follow up bone scan and/or CT scan with mean follow up period of 21.6 and 25.2 months respectively.

Results: The overall diagnostic accuracy of MET PET imaging in the detection of metastatic bone lesions in 43 cases was (94.6%). High sensitivity and NPV (100%) were obtained when equivocal lesions were interpreted as malignant. In twenty five cases MET PET showed accuracy of 93.8% in comparison to 84.4% for concurrent BS in the detection of bone metastasis. One predominantly osteolytic lesion which was missed on concurrent bone scan showed high uptake by MET PET.

Conclusions: PET imaging with MET showed high accuracy in the detection of bone metastasis in patients with lung cancer. In our study, MET PET showed higher accuracy than bone scan in the detection of skeletal metastasis and clearly demonstrated an osteolytic bone lesion that was considered false negative on concurrent bone scan.





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