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Oncology-Basic Science: Therapy, Metrics & InterventionTherapy, Metrics & Intervention Posters |
1 Medical Physics Dept; 2 Nuclear Medicine Dept, S. Maria Nuova Hospital, Reggio Emilia, Italy
1367
Objectives: A quantitative retrospective analysis of the estimated absorbed doses to target organs by patients who underwent 90Y-DOTATOC in 2007.
Methods: 17 patients underwent a series of 4-5 planar whole body (WB) scans (1h, 4h, 20h, 30h, 44h t.p.i.) after administration of 111In-DOTATOC (185MBq) without renal protection. A series of biological samples was collected: at 20m, 30m, 40m, 1h, 4h, 20h, 30h, 44h t.p.i. for blood and 1h t.p.i. for urine. Quantitative data from WB scans and estimate of the dose delivered to critical organs were obtained by the software ULMDOS(University of Ulm, Germany) and OLINDA/EXM. Scans were acquired with a dual head gamma-camera (ADAC-Genesys) and after corrected for background, scatter, self-absorption, patient thickness attenuation and organ overlapping. Patient-specific organ masses were also considered. Absorbed doses for kidneys, liver, lungs, spleen, red marrow (RM), WB and the fraction of activity in blood and urine are here reviewed.
Results: The following average and range (min-max) data (Gy/GBq) were collected: kidneys (6.76; 2.06-13.20); liver (2.66; 0.47-13.90); lungs (0.60; 0.01-1.42); RM from blood (0.17; 0.06-0.28); spleen (9.45; 0.27-29.2); WB (0.37; 0.11-0.79). Considering urine excreted in the first hour post injection, the mean (min-max) WB activity fraction was:88.3%(74-100%).The fraction of activity in blood is fitted by a two exponential function and quickly decreases to 8% within the first hour and to less then 1% after 17h.
Conclusions: The interpatient variability of dosimetric data shows the importance to perform individual studies, in spite of the strong impact on Nuclear Medicine Dept.
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